Abstract
In this study, diffusion-induced hydrophobic-hydrophilic conversion of the surface of the cross-linked polydimethylsiloxane (PDMS) substrate was realized by employing a simple swelling-deswelling process of PDMS substrate in a block-type polymer solution with the aim of development of a temporal cell-adhesive substrate. The ABA block-type polymer composed of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) segment and PDMS segment with over 70% of dimethylsiloxane unit composition could be successfully incorporated in the PDMS substrate during the swelling-deswelling process to prepare the PDMS/phospholipid block copolymer hybrid substrates. During the aging process of the PDMS substrate for 4 days in aqueous medium, its surface property changed gradually from hydrophobic to hydrophilic. X-ray photoelectron spectroscopy and atomic force microscopy data provided strong evidence that the time-dependent hydrophilic conversion of the PDMS/block-type phospholipid polymer hybrid substrate was induced by the diffusion of the hydrophilic PMPC segment in the block-type polymer to be tethered on the substrate. During the hydrophilic conversion process, surface-adsorbed fibronectin was gradually desorbed from the substrate surface, and this resulted in successful detachment of two-dimensional connected cell crowds.
| Original language | English |
|---|---|
| Pages (from-to) | 21839-21846 |
| Number of pages | 8 |
| Journal | ACS Applied Materials and Interfaces |
| Volume | 8 |
| Issue number | 33 |
| DOIs | |
| Publication status | Published - 2016 Aug 24 |
Keywords
- cell adhesion
- hybrid material
- poly(2-methacryloyloxyethyl phosphorylcholine)
- polydimethylsiloxane
- swelling-deswelling process
ASJC Scopus subject areas
- Materials Science(all)