Diffusion-Induced Hydrophilic Conversion of Polydimethylsiloxane/Block-Type Phospholipid Polymer Hybrid Substrate for Temporal Cell-Adhesive Surface

Ji-Hun Seo, Kazuhiko Ishihara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this study, diffusion-induced hydrophobic-hydrophilic conversion of the surface of the cross-linked polydimethylsiloxane (PDMS) substrate was realized by employing a simple swelling-deswelling process of PDMS substrate in a block-type polymer solution with the aim of development of a temporal cell-adhesive substrate. The ABA block-type polymer composed of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) segment and PDMS segment with over 70% of dimethylsiloxane unit composition could be successfully incorporated in the PDMS substrate during the swelling-deswelling process to prepare the PDMS/phospholipid block copolymer hybrid substrates. During the aging process of the PDMS substrate for 4 days in aqueous medium, its surface property changed gradually from hydrophobic to hydrophilic. X-ray photoelectron spectroscopy and atomic force microscopy data provided strong evidence that the time-dependent hydrophilic conversion of the PDMS/block-type phospholipid polymer hybrid substrate was induced by the diffusion of the hydrophilic PMPC segment in the block-type polymer to be tethered on the substrate. During the hydrophilic conversion process, surface-adsorbed fibronectin was gradually desorbed from the substrate surface, and this resulted in successful detachment of two-dimensional connected cell crowds.

Original languageEnglish
Pages (from-to)21839-21846
Number of pages8
JournalACS Applied Materials and Interfaces
Volume8
Issue number33
DOIs
Publication statusPublished - 2016 Aug 24

Keywords

  • cell adhesion
  • hybrid material
  • poly(2-methacryloyloxyethyl phosphorylcholine)
  • polydimethylsiloxane
  • swelling-deswelling process

ASJC Scopus subject areas

  • Materials Science(all)

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