Diffusion-tensor imaging for glioma grading at 3-T magnetic resonance imaging

Analysis of fractional anisotropy and mean diffusivity

Ho Yun Lee, Dong Gyu Na, In Chan Song, Dong Hoon Lee, Hyung Suk Seo, Ji Hoon Kim, Kee Hyun Chang

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

PURPOSE: To retrospectively determine whether fractional anisotropy (FA) or mean diffusivity (MD) value at 3-T diffusion-tensor imaging is different between low- and high-grade gliomas and may be useful for glioma grading. METHODS: Review board approval was obtained, and informed consent was waived. Diffusion-tensor imaging was performed in 27 patients with surgically proved gliomas (19 high-grade and 8 low-grade gliomas). Fractional anisotropy and MD values were measured in 3 regions; peritumoral edema, and enhancing and nonenhancing tumor regions. We compared mean FA and MD values of nonenhancing tumor regions between low- and high-grade gliomas and compared the FA and MD values among the 3 mentioned regions in high-grade gliomas. The relationship between FA and MD values of tumors was also investigated. Statistical analysis was performed using the Student t test and Pearson correlation coefficients. RESULTS: In the nonenhancing regions of tumors, FA ratios were not significantly different between low- and high-grade gliomas (0.472 and 0.701, P = 0.075), but MD ratios were significantly lower in high-grade gliomas (1.899 and 1.23, P < 0.001). In high-grade gliomas, enhancing tumors showed a tendency toward a lower FA ratio than nonenhancing tumors (P = 0.034), but FA values or ratios of peritumoral edema were not significantly different from those of enhancing or nonenhancing tumor. No strong relationship was found between FA and MD values. CONCLUSIONS: Fractional anisotropy values of low- and high-grade gliomas were not significantly different. However, MD values of nonenhancing low-grade gliomas were significantly higher than those of nonenhancing high-grade gliomas, which will be useful for the grading of nonenhancing infiltrative gliomas.

Original languageEnglish
Pages (from-to)298-303
Number of pages6
JournalJournal of Computer Assisted Tomography
Volume32
Issue number2
DOIs
Publication statusPublished - 2008 Mar 1
Externally publishedYes

Fingerprint

Diffusion Tensor Imaging
Anisotropy
Glioma
Magnetic Resonance Imaging
Neoplasms
Edema
Informed Consent

Keywords

  • Brain
  • Brain neoplasms
  • Diagnosis
  • Diffusion
  • Diffusion tensor
  • Magnetic resonance (MR)
  • MR

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Diffusion-tensor imaging for glioma grading at 3-T magnetic resonance imaging : Analysis of fractional anisotropy and mean diffusivity. / Lee, Ho Yun; Na, Dong Gyu; Song, In Chan; Lee, Dong Hoon; Seo, Hyung Suk; Kim, Ji Hoon; Chang, Kee Hyun.

In: Journal of Computer Assisted Tomography, Vol. 32, No. 2, 01.03.2008, p. 298-303.

Research output: Contribution to journalArticle

Lee, Ho Yun ; Na, Dong Gyu ; Song, In Chan ; Lee, Dong Hoon ; Seo, Hyung Suk ; Kim, Ji Hoon ; Chang, Kee Hyun. / Diffusion-tensor imaging for glioma grading at 3-T magnetic resonance imaging : Analysis of fractional anisotropy and mean diffusivity. In: Journal of Computer Assisted Tomography. 2008 ; Vol. 32, No. 2. pp. 298-303.
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AU - Song, In Chan

AU - Lee, Dong Hoon

AU - Seo, Hyung Suk

AU - Kim, Ji Hoon

AU - Chang, Kee Hyun

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N2 - PURPOSE: To retrospectively determine whether fractional anisotropy (FA) or mean diffusivity (MD) value at 3-T diffusion-tensor imaging is different between low- and high-grade gliomas and may be useful for glioma grading. METHODS: Review board approval was obtained, and informed consent was waived. Diffusion-tensor imaging was performed in 27 patients with surgically proved gliomas (19 high-grade and 8 low-grade gliomas). Fractional anisotropy and MD values were measured in 3 regions; peritumoral edema, and enhancing and nonenhancing tumor regions. We compared mean FA and MD values of nonenhancing tumor regions between low- and high-grade gliomas and compared the FA and MD values among the 3 mentioned regions in high-grade gliomas. The relationship between FA and MD values of tumors was also investigated. Statistical analysis was performed using the Student t test and Pearson correlation coefficients. RESULTS: In the nonenhancing regions of tumors, FA ratios were not significantly different between low- and high-grade gliomas (0.472 and 0.701, P = 0.075), but MD ratios were significantly lower in high-grade gliomas (1.899 and 1.23, P < 0.001). In high-grade gliomas, enhancing tumors showed a tendency toward a lower FA ratio than nonenhancing tumors (P = 0.034), but FA values or ratios of peritumoral edema were not significantly different from those of enhancing or nonenhancing tumor. No strong relationship was found between FA and MD values. CONCLUSIONS: Fractional anisotropy values of low- and high-grade gliomas were not significantly different. However, MD values of nonenhancing low-grade gliomas were significantly higher than those of nonenhancing high-grade gliomas, which will be useful for the grading of nonenhancing infiltrative gliomas.

AB - PURPOSE: To retrospectively determine whether fractional anisotropy (FA) or mean diffusivity (MD) value at 3-T diffusion-tensor imaging is different between low- and high-grade gliomas and may be useful for glioma grading. METHODS: Review board approval was obtained, and informed consent was waived. Diffusion-tensor imaging was performed in 27 patients with surgically proved gliomas (19 high-grade and 8 low-grade gliomas). Fractional anisotropy and MD values were measured in 3 regions; peritumoral edema, and enhancing and nonenhancing tumor regions. We compared mean FA and MD values of nonenhancing tumor regions between low- and high-grade gliomas and compared the FA and MD values among the 3 mentioned regions in high-grade gliomas. The relationship between FA and MD values of tumors was also investigated. Statistical analysis was performed using the Student t test and Pearson correlation coefficients. RESULTS: In the nonenhancing regions of tumors, FA ratios were not significantly different between low- and high-grade gliomas (0.472 and 0.701, P = 0.075), but MD ratios were significantly lower in high-grade gliomas (1.899 and 1.23, P < 0.001). In high-grade gliomas, enhancing tumors showed a tendency toward a lower FA ratio than nonenhancing tumors (P = 0.034), but FA values or ratios of peritumoral edema were not significantly different from those of enhancing or nonenhancing tumor. No strong relationship was found between FA and MD values. CONCLUSIONS: Fractional anisotropy values of low- and high-grade gliomas were not significantly different. However, MD values of nonenhancing low-grade gliomas were significantly higher than those of nonenhancing high-grade gliomas, which will be useful for the grading of nonenhancing infiltrative gliomas.

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KW - Brain neoplasms

KW - Diagnosis

KW - Diffusion

KW - Diffusion tensor

KW - Magnetic resonance (MR)

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