Diffusion tensor imaging of extraocular muscle using two-dimensional single-shot interleaved multiple inner volume imaging diffusion-weighted EPI at 3 tesla

Hyung Suk Seo, Seong Eun Kim, John Rose, J. Rock Hadley, Dennis L. Parker, Eun Kee Jeong

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose To evaluate the feasibility of diffusion tensor imaging (DTI) for the medial and lateral rectus extraocular muscle (EOM) evaluation, to investigate the normal DTI parameters of the medial and lateral rectus EOM, and to compare with other skeletal muscle. Materials and Methods Seven multiple sclerosis patients and five normal subjects (M:F = 5:7, mean age = 31.6 ± 9.2) without EOM disorder were included. The orbital DTIs using 2D-ss-IMVI-DWEPI were scanned with b = 500 s/mm2 and 12 directions. The mean diffusivity (MD) and fractional anisotrophy (FA) of medial and lateral rectus EOMs in both orbits, and temporalis muscles were measured in regions of interest on two consecutive axial slices. Student t-test was performed to compare the mean apparent diffusion coefficient and FA values between medial and lateral rectus EOMs, and between EOMs and temporalis muscles. Results The MDs in medial (0.58 ± 0.18 × 10-3mm2/s) and lateral rectus EOMs (0.71 ± 0.18 × 10-3mm2/s) were significantly lower than temporalis muscle (0.84 ± 0.14 × 10-3 mm2/s) (P < 0.001, respectively). The MD in medial rectus EOM was significantly lower than lateral rectus EOM (P = 0.001). The FAs in medial (0.40 ± 0.05) and lateral rectus EOMs (0.40 ± 0.05) were significantly higher than temporalis muscle (0.25 ± 0.05) (P < 0.001, respectively). There was no significant difference between the FAs in medial and lateral rectus EOMs (P > 0.05). Conclusion The MDs of EOMs were lower and the FAs were higher than those of skeletal muscle. These are well correlated to the unique characteristics of EOMs. J. Magn. Reson. Imaging 2013;38:1162-1168. © 2013 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)1162-1168
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume38
Issue number5
DOIs
Publication statusPublished - 2013 Nov 1

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Oculomotor Muscles
Diffusion Tensor Imaging
Muscles
Skeletal Muscle
Orbit
Muscular Diseases
Multiple Sclerosis
Students

Keywords

  • diffusion tensor imaging
  • muscle
  • orbit

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Diffusion tensor imaging of extraocular muscle using two-dimensional single-shot interleaved multiple inner volume imaging diffusion-weighted EPI at 3 tesla. / Seo, Hyung Suk; Kim, Seong Eun; Rose, John; Hadley, J. Rock; Parker, Dennis L.; Jeong, Eun Kee.

In: Journal of Magnetic Resonance Imaging, Vol. 38, No. 5, 01.11.2013, p. 1162-1168.

Research output: Contribution to journalArticle

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abstract = "Purpose To evaluate the feasibility of diffusion tensor imaging (DTI) for the medial and lateral rectus extraocular muscle (EOM) evaluation, to investigate the normal DTI parameters of the medial and lateral rectus EOM, and to compare with other skeletal muscle. Materials and Methods Seven multiple sclerosis patients and five normal subjects (M:F = 5:7, mean age = 31.6 ± 9.2) without EOM disorder were included. The orbital DTIs using 2D-ss-IMVI-DWEPI were scanned with b = 500 s/mm2 and 12 directions. The mean diffusivity (MD) and fractional anisotrophy (FA) of medial and lateral rectus EOMs in both orbits, and temporalis muscles were measured in regions of interest on two consecutive axial slices. Student t-test was performed to compare the mean apparent diffusion coefficient and FA values between medial and lateral rectus EOMs, and between EOMs and temporalis muscles. Results The MDs in medial (0.58 ± 0.18 × 10-3mm2/s) and lateral rectus EOMs (0.71 ± 0.18 × 10-3mm2/s) were significantly lower than temporalis muscle (0.84 ± 0.14 × 10-3 mm2/s) (P < 0.001, respectively). The MD in medial rectus EOM was significantly lower than lateral rectus EOM (P = 0.001). The FAs in medial (0.40 ± 0.05) and lateral rectus EOMs (0.40 ± 0.05) were significantly higher than temporalis muscle (0.25 ± 0.05) (P < 0.001, respectively). There was no significant difference between the FAs in medial and lateral rectus EOMs (P > 0.05). Conclusion The MDs of EOMs were lower and the FAs were higher than those of skeletal muscle. These are well correlated to the unique characteristics of EOMs. J. Magn. Reson. Imaging 2013;38:1162-1168. {\circledC} 2013 Wiley Periodicals, Inc.",
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AB - Purpose To evaluate the feasibility of diffusion tensor imaging (DTI) for the medial and lateral rectus extraocular muscle (EOM) evaluation, to investigate the normal DTI parameters of the medial and lateral rectus EOM, and to compare with other skeletal muscle. Materials and Methods Seven multiple sclerosis patients and five normal subjects (M:F = 5:7, mean age = 31.6 ± 9.2) without EOM disorder were included. The orbital DTIs using 2D-ss-IMVI-DWEPI were scanned with b = 500 s/mm2 and 12 directions. The mean diffusivity (MD) and fractional anisotrophy (FA) of medial and lateral rectus EOMs in both orbits, and temporalis muscles were measured in regions of interest on two consecutive axial slices. Student t-test was performed to compare the mean apparent diffusion coefficient and FA values between medial and lateral rectus EOMs, and between EOMs and temporalis muscles. Results The MDs in medial (0.58 ± 0.18 × 10-3mm2/s) and lateral rectus EOMs (0.71 ± 0.18 × 10-3mm2/s) were significantly lower than temporalis muscle (0.84 ± 0.14 × 10-3 mm2/s) (P < 0.001, respectively). The MD in medial rectus EOM was significantly lower than lateral rectus EOM (P = 0.001). The FAs in medial (0.40 ± 0.05) and lateral rectus EOMs (0.40 ± 0.05) were significantly higher than temporalis muscle (0.25 ± 0.05) (P < 0.001, respectively). There was no significant difference between the FAs in medial and lateral rectus EOMs (P > 0.05). Conclusion The MDs of EOMs were lower and the FAs were higher than those of skeletal muscle. These are well correlated to the unique characteristics of EOMs. J. Magn. Reson. Imaging 2013;38:1162-1168. © 2013 Wiley Periodicals, Inc.

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