Digitally tunable physicochemical coding of material composition and topography in continuous microfibres

Edward Kang, Gi Seok Jeong, Yoon Young Choi, Kwang Ho Lee, Ali Khademhosseini, Sang Hoon Lee

Research output: Contribution to journalArticle

266 Citations (Scopus)

Abstract

Heterotypic functional materials with compositional and topographical properties that vary spatiotemporally on the micro-or nanoscale are common in nature. However, fabricating such complex materials in the laboratory remains challenging. Here we describe a method to continuously create microfibres with tunable morphological, structural and chemical features using a microfluidic system consisting of a digital, programmable flow control that mimics the silk-spinning process of spiders. With this method we fabricated hydrogel microfibres coded with varying chemical composition and topography along the fibre, including gas micro-bubbles as well as nanoporous spindle-knots and joints that enabled directional water collection. We also explored the potential use of the coded microfibres for tissue engineering applications by creating multifunctional microfibres with a spatially controlled co-culture of encapsulated cells.

Original languageEnglish
Pages (from-to)877-883
Number of pages7
JournalNature Materials
Volume10
Issue number11
DOIs
Publication statusPublished - 2011 Nov 1

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microfibers
Silk
Functional materials
Hydrogel
Bioelectric potentials
Tissue engineering
Flow control
Microfluidics
Hydrogels
Topography
topography
coding
Gases
Spiders
Water
Fibers
Tissue Engineering
Coculture Techniques
Chemical analysis
Joints

ASJC Scopus subject areas

  • Mechanical Engineering
  • Mechanics of Materials
  • Condensed Matter Physics
  • Materials Science(all)
  • Chemistry(all)

Cite this

Digitally tunable physicochemical coding of material composition and topography in continuous microfibres. / Kang, Edward; Jeong, Gi Seok; Choi, Yoon Young; Lee, Kwang Ho; Khademhosseini, Ali; Lee, Sang Hoon.

In: Nature Materials, Vol. 10, No. 11, 01.11.2011, p. 877-883.

Research output: Contribution to journalArticle

Kang, Edward ; Jeong, Gi Seok ; Choi, Yoon Young ; Lee, Kwang Ho ; Khademhosseini, Ali ; Lee, Sang Hoon. / Digitally tunable physicochemical coding of material composition and topography in continuous microfibres. In: Nature Materials. 2011 ; Vol. 10, No. 11. pp. 877-883.
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