Abstract
Heterotypic functional materials with compositional and topographical properties that vary spatiotemporally on the micro-or nanoscale are common in nature. However, fabricating such complex materials in the laboratory remains challenging. Here we describe a method to continuously create microfibres with tunable morphological, structural and chemical features using a microfluidic system consisting of a digital, programmable flow control that mimics the silk-spinning process of spiders. With this method we fabricated hydrogel microfibres coded with varying chemical composition and topography along the fibre, including gas micro-bubbles as well as nanoporous spindle-knots and joints that enabled directional water collection. We also explored the potential use of the coded microfibres for tissue engineering applications by creating multifunctional microfibres with a spatially controlled co-culture of encapsulated cells.
| Original language | English |
|---|---|
| Pages (from-to) | 877-883 |
| Number of pages | 7 |
| Journal | Nature Materials |
| Volume | 10 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2011 Nov 1 |
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ASJC Scopus subject areas
- Mechanical Engineering
- Mechanics of Materials
- Condensed Matter Physics
- Materials Science(all)
- Chemistry(all)
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Digitally tunable physicochemical coding of material composition and topography in continuous microfibres. / Kang, Edward; Jeong, Gi Seok; Choi, Yoon Young; Lee, Kwang Ho; Khademhosseini, Ali; Lee, Sang Hoon.
In: Nature Materials, Vol. 10, No. 11, 01.11.2011, p. 877-883.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Digitally tunable physicochemical coding of material composition and topography in continuous microfibres
AU - Kang, Edward
AU - Jeong, Gi Seok
AU - Choi, Yoon Young
AU - Lee, Kwang Ho
AU - Khademhosseini, Ali
AU - Lee, Sang Hoon
PY - 2011/11/1
Y1 - 2011/11/1
N2 - Heterotypic functional materials with compositional and topographical properties that vary spatiotemporally on the micro-or nanoscale are common in nature. However, fabricating such complex materials in the laboratory remains challenging. Here we describe a method to continuously create microfibres with tunable morphological, structural and chemical features using a microfluidic system consisting of a digital, programmable flow control that mimics the silk-spinning process of spiders. With this method we fabricated hydrogel microfibres coded with varying chemical composition and topography along the fibre, including gas micro-bubbles as well as nanoporous spindle-knots and joints that enabled directional water collection. We also explored the potential use of the coded microfibres for tissue engineering applications by creating multifunctional microfibres with a spatially controlled co-culture of encapsulated cells.
AB - Heterotypic functional materials with compositional and topographical properties that vary spatiotemporally on the micro-or nanoscale are common in nature. However, fabricating such complex materials in the laboratory remains challenging. Here we describe a method to continuously create microfibres with tunable morphological, structural and chemical features using a microfluidic system consisting of a digital, programmable flow control that mimics the silk-spinning process of spiders. With this method we fabricated hydrogel microfibres coded with varying chemical composition and topography along the fibre, including gas micro-bubbles as well as nanoporous spindle-knots and joints that enabled directional water collection. We also explored the potential use of the coded microfibres for tissue engineering applications by creating multifunctional microfibres with a spatially controlled co-culture of encapsulated cells.
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UR - http://www.scopus.com/inward/citedby.url?scp=80054956005&partnerID=8YFLogxK
U2 - 10.1038/nmat3108
DO - 10.1038/nmat3108
M3 - Article
C2 - 21892177
AN - SCOPUS:80054956005
VL - 10
SP - 877
EP - 883
JO - Nature Materials
JF - Nature Materials
SN - 1476-1122
IS - 11
ER -