Dimeric ent-kaurane diterpenoids from isodon excisus

Seong Su Hong; Seon A. Lee; Chul Lee; Xiang Hua Han; Sanggil Choe; Nahyun Kim; Dongho Lee; Chong Kil Lee; Youngsoo Kim; Jin Tae Hong; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1021/np200439n

Dimeric ent-kaurane diterpenoids from isodon excisus

Seong Su Hong, Seon A. Lee, Chul Lee, Xiang Hua Han, Sanggil Choe, Nahyun Kim, Dongho Lee, Chong Kil Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Five new dimeric ent-kauranoids, biexcisusins A-E (1-5), were isolated from the aerial parts of Isodon excisus. The structures and relative configurations of these compounds were determined on the basis of spectroscopic data interpretation. Of these, biexcisusins C-E (3-5) are dimeric ent-kaurane diterpenoids exhibiting an unprecedented linkage through a nine-membered lactone ring between two ent-kaurane subunits. Compounds 1-5 showed no inhibitory effects on the LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells, up to a dose of 50 μM.

Original language	English
Pages (from-to)	2382-2387
Number of pages	6
Journal	Journal of Natural Products
Volume	74
Issue number	11
DOIs	https://doi.org/10.1021/np200439n
Publication status	Published - 2011 Nov 28

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np200439n

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abstract = "Five new dimeric ent-kauranoids, biexcisusins A-E (1-5), were isolated from the aerial parts of Isodon excisus. The structures and relative configurations of these compounds were determined on the basis of spectroscopic data interpretation. Of these, biexcisusins C-E (3-5) are dimeric ent-kaurane diterpenoids exhibiting an unprecedented linkage through a nine-membered lactone ring between two ent-kaurane subunits. Compounds 1-5 showed no inhibitory effects on the LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells, up to a dose of 50 μM.",

author = "Hong, {Seong Su} and Lee, {Seon A.} and Chul Lee and Han, {Xiang Hua} and Sanggil Choe and Nahyun Kim and Dongho Lee and Lee, {Chong Kil} and Youngsoo Kim and Hong, {Jin Tae} and Lee, {Mi Kyeong} and Hwang, {Bang Yeon}",

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AU - Hong, Seong Su

AU - Lee, Seon A.

AU - Lee, Chul

AU - Han, Xiang Hua

AU - Choe, Sanggil

AU - Kim, Nahyun

AU - Lee, Dongho

AU - Lee, Chong Kil

AU - Kim, Youngsoo

AU - Hong, Jin Tae

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

PY - 2011/11/28

Y1 - 2011/11/28

N2 - Five new dimeric ent-kauranoids, biexcisusins A-E (1-5), were isolated from the aerial parts of Isodon excisus. The structures and relative configurations of these compounds were determined on the basis of spectroscopic data interpretation. Of these, biexcisusins C-E (3-5) are dimeric ent-kaurane diterpenoids exhibiting an unprecedented linkage through a nine-membered lactone ring between two ent-kaurane subunits. Compounds 1-5 showed no inhibitory effects on the LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells, up to a dose of 50 μM.

AB - Five new dimeric ent-kauranoids, biexcisusins A-E (1-5), were isolated from the aerial parts of Isodon excisus. The structures and relative configurations of these compounds were determined on the basis of spectroscopic data interpretation. Of these, biexcisusins C-E (3-5) are dimeric ent-kaurane diterpenoids exhibiting an unprecedented linkage through a nine-membered lactone ring between two ent-kaurane subunits. Compounds 1-5 showed no inhibitory effects on the LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells, up to a dose of 50 μM.

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Dimeric ent-kaurane diterpenoids from isodon excisus

Abstract

ASJC Scopus subject areas

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