Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius

Qinghao Jin, Jin Woo Lee, Hari Jang, Ji Eun Choi, Hyung Sik Kim, Dongho Lee, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Phytochemical investigation of the roots of Echinops latifolius led to the isolation of a new carbon skeleton dimeric sesquiterpene (1) and a new thiophene (2), along with six known compounds (3–8). Their structures and relative stereochemistry were elucidated by spectroscopic and spectrometric methods (1H and 13C NMR, COSY, HSQC, HMBC, ROESY, and MS). All isolates were evaluated for their inhibition of LPS-induced NO production in RAW 264.7 cells. Compounds 4 and 5 exhibited the most potent inhibitory effects on NO production.

Original languageEnglish
Pages (from-to)5995-5998
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number24
DOIs
Publication statusPublished - 2016 Dec 15

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Keywords

  • Anti-inflammatory
  • Asteraceae
  • Dimeric sesquiterpene
  • Echinops latifolius
  • Thiophene

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Jin, Q., Lee, J. W., Jang, H., Choi, J. E., Kim, H. S., Lee, D., Hong, J. T., Lee, M. K., & Hwang, B. Y. (2016). Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius. Bioorganic and Medicinal Chemistry Letters, 26(24), 5995-5998. https://doi.org/10.1016/j.bmcl.2016.10.017