Diminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorder

Minue J. Kim, Jeanyung Chey, Ain Chung, Soojeong Bae, Hyunsoo Khang, Byung-Joo Ham, Sujung J. Yoon, Do Un Jeong, In Kyoon Lyoo

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Background: Previous brain imaging studies have reported hyperactivation of the amygdala and hypoactivation of the anterior cingulate in posttraumatic stress disorder (PTSD) patients, which is believed to be an underlying neural mechanism of the PTSD symptoms. The current study specifically focuses on the abnormal activity of the rostral anterior cingulate, using a paradigm which elicits an unexpected processing conflict caused by salient emotional stimuli. Methods: Twelve survivors (seven men and five women) of the Taegu subway fire in 2003, who later developed PTSD, agreed to participate in this study. Twelve healthy volunteers (seven men and five women) were recruited for comparison. Functional brain images of all participants were acquired using functional magnetic resonance imaging while performing a same-different judgment task, which was modified to elicit an unexpected emotional processing conflict. Results: PTSD patients, compared to comparison subjects, showed a decreased rostral anterior cingulate functioning when exposed to situations which induce an unexpected emotional processing conflict. Moreover, PTSD symptom severity was negatively correlated to the level of decrease in the rostral anterior cingulate activity. Conclusions: The results of this study provide evidence that the rostral anterior cingulate functioning is impaired in PTSD patients during response-conflict situations that involve emotional stimuli.

Original languageEnglish
Pages (from-to)268-277
Number of pages10
JournalJournal of Psychiatric Research
Volume42
Issue number4
DOIs
Publication statusPublished - 2008 Mar 1
Externally publishedYes

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Gyrus Cinguli
Post-Traumatic Stress Disorders
Railroads
Amygdala
Neuroimaging
Survivors
Threat
Healthy Volunteers
Magnetic Resonance Imaging
Conflict (Psychology)
Emotion
Brain

Keywords

  • Anterior cingulate
  • Anxiety
  • Fear
  • Functional magnetic resonance imaging (fMRI)
  • Posttraumatic stress disorder (PTSD)
  • Trauma

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Diminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorder. / Kim, Minue J.; Chey, Jeanyung; Chung, Ain; Bae, Soojeong; Khang, Hyunsoo; Ham, Byung-Joo; Yoon, Sujung J.; Jeong, Do Un; Lyoo, In Kyoon.

In: Journal of Psychiatric Research, Vol. 42, No. 4, 01.03.2008, p. 268-277.

Research output: Contribution to journalArticle

Kim, Minue J. ; Chey, Jeanyung ; Chung, Ain ; Bae, Soojeong ; Khang, Hyunsoo ; Ham, Byung-Joo ; Yoon, Sujung J. ; Jeong, Do Un ; Lyoo, In Kyoon. / Diminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorder. In: Journal of Psychiatric Research. 2008 ; Vol. 42, No. 4. pp. 268-277.
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