Direct activation of guinea pig vagal afferent neurons by FMRFamide

Min Goo Lee, Ji Yong Park, Young Keun Park, Bradley J. Undem

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Vagus nerve comprises two distinct kinds of nerves, nodose and jugular ganglionic nerves. We tested pharmacological difference between two vagal nerves in the responsiveness to FMRFamide. The response probability to FMRFamide was significantly higher in nodose than jugular nerves in intracellular calcium measurement. Nodose nerves also depolarized membrane potential to FMRFamide more than jugular nerves did, in patch-clamp recording, although the probability of action potential discharge was same in both nerves. The inward current induced by FMRFamide was characterized as mixed cations. These results suggest that FMRFamide may act as an activator and modulator of vagal sensory nerves for treating symptoms in visceral diseases.

    Original languageEnglish
    Pages (from-to)609-612
    Number of pages4
    JournalNeuroreport
    Volume22
    Issue number12
    DOIs
    Publication statusPublished - 2011 Aug 24

    Keywords

    • FMRFamide
    • intracellular calcium measurement
    • jugular ganglion
    • nodose ganglion
    • patch-clamp techniques
    • vagus nerve

    ASJC Scopus subject areas

    • Neuroscience(all)

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