Direct electrical measurement of protein-water interactions and temperature dependence using piezoelectric microcantilevers

Jeong Hoon Lee; Kyo Seon Hwang; Dae Sung Yoon; Ji Yoon Kang; Sang Kyung Kim; Tae Song Kim

doi:10.1002/adma.201101037

Direct electrical measurement of protein-water interactions and temperature dependence using piezoelectric microcantilevers

Jeong Hoon Lee, Kyo Seon Hwang, Dae Sung Yoon, Ji Yoon Kang, Sang Kyung Kim, Tae Song Kim

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A platform that provides a fundamental tool to understand protein behaviors by a simple real-time electrical readout is demonstrated. Observing the temperature dependence of protein activity as well as the humidity-sensitive protein activity of a prostate-specific antigen (PSA) monoclonal antibody receptor (MAbs), as well as PSA-MAbs receptor complexes, provides a stability curve for the protein and a humidity dependence of their activity.

Original language	English
Pages (from-to)	2920-2923
Number of pages	4
Journal	Advanced Materials
Volume	23
Issue number	26
DOIs	https://doi.org/10.1002/adma.201101037
Publication status	Published - 2011 Jul 12
Externally published	Yes

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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AU - Lee, Jeong Hoon

AU - Hwang, Kyo Seon

AU - Yoon, Dae Sung

AU - Kang, Ji Yoon

AU - Kim, Sang Kyung

AU - Kim, Tae Song

PY - 2011/7/12

Y1 - 2011/7/12

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AB - A platform that provides a fundamental tool to understand protein behaviors by a simple real-time electrical readout is demonstrated. Observing the temperature dependence of protein activity as well as the humidity-sensitive protein activity of a prostate-specific antigen (PSA) monoclonal antibody receptor (MAbs), as well as PSA-MAbs receptor complexes, provides a stability curve for the protein and a humidity dependence of their activity.

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Direct electrical measurement of protein-water interactions and temperature dependence using piezoelectric microcantilevers

Abstract

ASJC Scopus subject areas

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