Direct fabrication of enzyme-carrying polymer nanofibers by electrospinning

Thurston E. Herricks, Sae Hoon Kim, Jungbae Kim, Dan Li, Ja Hun Kwak, Jay W. Grate, Seong H. Kim, Younan Xia

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100 Citations (Scopus)

Abstract

Nanofibers consisting of enzyme-polymer composites have been prepared by directly electrospinning a solution of surfactant-stabilized enzyme and polymer in toluene. Additional treatment with glutaraldehyde could greatly stabilize the enzyme activity of the fibers, which could be maintained in a buffer under shaking conditions for more than two weeks. The nanofibers also showed great improvement in the enzyme activity over bulk films as a result of increased mass-transfer for substrate molecules to and from the enzyme reactive sites. These stable and catalytically active nanofiber-based mats were highly durable and could be easily recovered from solution, making them ideal candidates for large scale applications.

Original languageEnglish
Pages (from-to)3241-3245
Number of pages5
JournalJournal of Materials Chemistry
Volume15
Issue number31
DOIs
Publication statusPublished - 2005 Aug 21

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

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    Herricks, T. E., Kim, S. H., Kim, J., Li, D., Kwak, J. H., Grate, J. W., Kim, S. H., & Xia, Y. (2005). Direct fabrication of enzyme-carrying polymer nanofibers by electrospinning. Journal of Materials Chemistry, 15(31), 3241-3245. https://doi.org/10.1039/b503660g