Direct synthesis of pyrazoles from esters using tert-butoxide-assisted C-(C=O) coupling

Bo Ram Kim, Gi Hyeon Sung, Ki Eun Ryu, Sang Gyeong Lee, Hyo Jae Yoon, Dong Soo Shin, Yong Jin Yoon

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12 Citations (Scopus)

Abstract

This paper describes the direct synthesis of pyrazoles from esters that comprises two sequential reactions: tert-butoxide-assisted C-C(=O) coupling reaction to yield β-ketonitrile or α,β-alkynone intermediates, and condensation by hydrazine addition. The method reported allows for easy control of the regioselectivity and structure of substituents at N-1, C-3, C-4 and/or C-5 positions.

Original languageEnglish
Pages (from-to)9201-9204
Number of pages4
JournalChemical Communications
Volume51
Issue number44
DOIs
Publication statusPublished - 2015 Jun 4

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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  • Cite this

    Kim, B. R., Sung, G. H., Ryu, K. E., Lee, S. G., Yoon, H. J., Shin, D. S., & Yoon, Y. J. (2015). Direct synthesis of pyrazoles from esters using tert-butoxide-assisted C-(C=O) coupling. Chemical Communications, 51(44), 9201-9204. https://doi.org/10.1039/c5cc02020d