Directing stem cell differentiation by changing the molecular mobility of supramolecular surfaces

Ji-Hun Seo, Sachiro Kakinoki, Tetsuji Yamaoka, Nobuhiko Yui

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Polymer surfaces with a wide range of hydrated surface mobility are developed by a simple deposition method with supramolecular block copolymers. The morphologies of adhering stem cells are greatly dependent on the surface mobility of polymers, and this induces significant changes in the cytoskeletal signaling pathway to direct the downstream stem cell differentiation.

Original languageEnglish
Pages (from-to)215-222
Number of pages8
JournalAdvanced Healthcare Materials
Volume4
Issue number2
DOIs
Publication statusPublished - 2015 Jan 1
Externally publishedYes

Keywords

  • Mesenchymal stem cells
  • PCR
  • Polyrotaxane
  • QCM-D
  • Supramolecules

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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