Abstract
Homing of mesenchymal stem cell (MSC) for tissue regeneration is known to be controlled by a homing factor, stromal cell-derived factor 1α (SDF-1α) gradient released from injury site. Binding of SDF-1α leads to MSC's extravasation and migration towards the infarcted tissue. In this study, a microfluidic device was designed to witness the homing process of MSC towards SDF-1α gradient. SDF-1 antagonist AMD3100 blocked the binding of SDF-1α to the MSC's receptor which led to loss of directional migration. On the other hand, Rock inhibitor, Y-27632 and Rac inhibitor, NSC23766 had no effects on directional migration but decreased MSC's migration distance.
| Original language | English |
|---|---|
| Title of host publication | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 453-454 |
| Number of pages | 2 |
| ISBN (Electronic) | 9780979806490 |
| Publication status | Published - 2016 |
| Event | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland Duration: 2016 Oct 9 → 2016 Oct 13 |
Other
| Other | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
|---|---|
| Country | Ireland |
| City | Dublin |
| Period | 16/10/9 → 16/10/13 |
Keywords
- Collagen scaffold
- Directional migration
- EC
- Extravasation
- Microfluidics
- MSC
- SDF-1α
ASJC Scopus subject areas
- Control and Systems Engineering