Abstract
Homing of mesenchymal stem cell (MSC) for tissue regeneration is known to be controlled by a homing factor, stromal cell-derived factor 1α (SDF-1α) gradient released from injury site. Binding of SDF-1α leads to MSC's extravasation and migration towards the infarcted tissue. In this study, a microfluidic device was designed to witness the homing process of MSC towards SDF-1α gradient. SDF-1 antagonist AMD3100 blocked the binding of SDF-1α to the MSC's receptor which led to loss of directional migration. On the other hand, Rock inhibitor, Y-27632 and Rac inhibitor, NSC23766 had no effects on directional migration but decreased MSC's migration distance.
| Original language | English |
|---|---|
| Title of host publication | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 453-454 |
| Number of pages | 2 |
| ISBN (Electronic) | 9780979806490 |
| Publication status | Published - 2016 |
| Event | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland Duration: 2016 Oct 9 → 2016 Oct 13 |
Other
| Other | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
|---|---|
| Country | Ireland |
| City | Dublin |
| Period | 16/10/9 → 16/10/13 |
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Keywords
- Collagen scaffold
- Directional migration
- EC
- Extravasation
- Microfluidics
- MSC
- SDF-1α
ASJC Scopus subject areas
- Control and Systems Engineering
Cite this
Directional and trans-endothelial migration of mesenchymal stem cell towards SDF-1a gradient on a microfluidic device. / Park, Siwan; Jang, Hwanseok; Jeong, Gi Seok; Kim, Byung Soo; Park, Yongdoo.
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, 2016. p. 453-454.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Directional and trans-endothelial migration of mesenchymal stem cell towards SDF-1a gradient on a microfluidic device
AU - Park, Siwan
AU - Jang, Hwanseok
AU - Jeong, Gi Seok
AU - Kim, Byung Soo
AU - Park, Yongdoo
PY - 2016
Y1 - 2016
N2 - Homing of mesenchymal stem cell (MSC) for tissue regeneration is known to be controlled by a homing factor, stromal cell-derived factor 1α (SDF-1α) gradient released from injury site. Binding of SDF-1α leads to MSC's extravasation and migration towards the infarcted tissue. In this study, a microfluidic device was designed to witness the homing process of MSC towards SDF-1α gradient. SDF-1 antagonist AMD3100 blocked the binding of SDF-1α to the MSC's receptor which led to loss of directional migration. On the other hand, Rock inhibitor, Y-27632 and Rac inhibitor, NSC23766 had no effects on directional migration but decreased MSC's migration distance.
AB - Homing of mesenchymal stem cell (MSC) for tissue regeneration is known to be controlled by a homing factor, stromal cell-derived factor 1α (SDF-1α) gradient released from injury site. Binding of SDF-1α leads to MSC's extravasation and migration towards the infarcted tissue. In this study, a microfluidic device was designed to witness the homing process of MSC towards SDF-1α gradient. SDF-1 antagonist AMD3100 blocked the binding of SDF-1α to the MSC's receptor which led to loss of directional migration. On the other hand, Rock inhibitor, Y-27632 and Rac inhibitor, NSC23766 had no effects on directional migration but decreased MSC's migration distance.
KW - Collagen scaffold
KW - Directional migration
KW - EC
KW - Extravasation
KW - Microfluidics
KW - MSC
KW - SDF-1α
UR - http://www.scopus.com/inward/record.url?scp=85014247330&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85014247330&partnerID=8YFLogxK
M3 - Conference contribution
SP - 453
EP - 454
BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PB - Chemical and Biological Microsystems Society
ER -