Directional assembly of α-helical peptides induced by cyclization

Seunghyun Sim, Yongju Kim, Taehoon Kim, Sunhee Lim, Myongsoo Lee

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Effective stabilization of short peptide chains into a helical structure has been a challenge in the fields of chemistry and biology. Here we report a novel method for α-helix stabilization of short peptides through their confinement in a cyclic architecture. We synthesized block peptides based on a short peptide and a flexible linker as linear precursors. Subsequent cyclization of the peptide precursors resulted in a conformational change of the peptide unit from a random coil to an α-helix. The incorporation of hydrophobic residues into the peptide unit led to a facially amphiphilic conformation of the molecular cycle. The resulting amphiphilic peptide self-assembled into undulated nanofibers through the directional assembly of small oblate micelles.

Original languageEnglish
Pages (from-to)20270-20272
Number of pages3
JournalJournal of the American Chemical Society
Volume134
Issue number50
DOIs
Publication statusPublished - 2012 Dec 19
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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