Disability weight for each level of the Expanded Disability Status Scale in multiple sclerosis

Joong Yang Cho, Keun Sik Hong, Ho Jin Kim, Su Hyun Kim, Ju Hong Min, Nam Hee Kim, Suk Won Ahn, Min Su Park, Jae Young An, Byung Jo Kim, Woojun Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The Expanded Disability Status Scale (EDSS) is the most widely employed ordinal disability scale in multiple sclerosis (MS). However, how far apart the individual EDSS levels are along the disability spectrum has not been formally quantified. Objectives: The objective of this paper is to generate refined disability weights (DWs) for each of the ordinal EDSS Level . Met ods: We performed the person trade-off (PTO) procedure to derive DWs of five representative EDSS cat gories (2, 4, 6, 7 and 9), and DWs of the remaining EDSS categories were assigned by linear interpolation. The modified Delphi process was used to achieve consensus among raters. Results: DWs were 0.021 for EDSS 2, 0.199 for EDSS 4, 0.313 for EDSS 6, 0.617 for EDSS 7, and 0.96 for EDSS 9. Pane members achieved a high degree of consensus for each DW, as indicated by low coefficients of variation. Conclusions: Our DWs confirmed that EDSS is an ordinal scale with highly variable intervals. The availability of DW for each EDSS level allows direct comparison of each MS outcome state with other health states and provides a foundation for the estimation of the disability-adjusted life-years lost of individual patients.

Original languageEnglish
Pages (from-to)1217-1223
Number of pages7
JournalMultiple Sclerosis Journal
Volume20
Issue number9
DOIs
Publication statusPublished - 2014 Jan 1

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Multiple Sclerosis
Weights and Measures
Quality-Adjusted Life Years
Cats
Health

Keywords

  • disability weight
  • Expanded Disability Status Scale
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Cho, J. Y., Hong, K. S., Kim, H. J., Kim, S. H., Min, J. H., Kim, N. H., ... Kim, W. (2014). Disability weight for each level of the Expanded Disability Status Scale in multiple sclerosis. Multiple Sclerosis Journal, 20(9), 1217-1223. https://doi.org/10.1177/1352458513518259

Disability weight for each level of the Expanded Disability Status Scale in multiple sclerosis. / Cho, Joong Yang; Hong, Keun Sik; Kim, Ho Jin; Kim, Su Hyun; Min, Ju Hong; Kim, Nam Hee; Ahn, Suk Won; Park, Min Su; An, Jae Young; Kim, Byung Jo; Kim, Woojun.

In: Multiple Sclerosis Journal, Vol. 20, No. 9, 01.01.2014, p. 1217-1223.

Research output: Contribution to journalArticle

Cho, JY, Hong, KS, Kim, HJ, Kim, SH, Min, JH, Kim, NH, Ahn, SW, Park, MS, An, JY, Kim, BJ & Kim, W 2014, 'Disability weight for each level of the Expanded Disability Status Scale in multiple sclerosis', Multiple Sclerosis Journal, vol. 20, no. 9, pp. 1217-1223. https://doi.org/10.1177/1352458513518259
Cho, Joong Yang ; Hong, Keun Sik ; Kim, Ho Jin ; Kim, Su Hyun ; Min, Ju Hong ; Kim, Nam Hee ; Ahn, Suk Won ; Park, Min Su ; An, Jae Young ; Kim, Byung Jo ; Kim, Woojun. / Disability weight for each level of the Expanded Disability Status Scale in multiple sclerosis. In: Multiple Sclerosis Journal. 2014 ; Vol. 20, No. 9. pp. 1217-1223.
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