Disassembly of Chromophore-Guided DNA Duplexes through Site-Selective Binding of Coralyne to Pyrene-Modified Adenine Bases

Ki Tae Kim, Tae Su Choi, Ka Young Kim, Hugh I. Kim, Byeang Hyean Kim

Research output: Contribution to journalArticle

Abstract

Under ambient conditions the disassembly of self-duplexes of PyA-modified oligodeoxyadenylates (i.e., chromophore-guided DNA assemblies) through intercalative binding of coralyne units to pyrene-modified adenine (PyA) bases was carried out. The coralyne units, intercalated site-selectively on the 3′ sides of the PyA units, are stabilized through π–π stacking interactions. This competitive intercalation destabilizes the stacking interactions of pairs of PyA units, resulting in dissociation of the self-duplexes. This behavior, which is opposite to that of coralyne-induced self-duplex formation of natural oligodeoxyadenylates, was exploited to prepare new types of DNA modules that can be switched between two different duplex states.

Original languageEnglish
Pages (from-to)590-593
Number of pages4
JournalChemPlusChem
Volume81
Issue number7
DOIs
Publication statusPublished - 2016 Jul 1

Keywords

  • coralyne
  • DNA disassembly
  • intercalations
  • molecular devices
  • polydeoxyadenylates

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of 'Disassembly of Chromophore-Guided DNA Duplexes through Site-Selective Binding of Coralyne to Pyrene-Modified Adenine Bases'. Together they form a unique fingerprint.

  • Cite this