Under ambient conditions the disassembly of self-duplexes of PyA-modified oligodeoxyadenylates (i.e., chromophore-guided DNA assemblies) through intercalative binding of coralyne units to pyrene-modified adenine (PyA) bases was carried out. The coralyne units, intercalated site-selectively on the 3′ sides of the PyA units, are stabilized through π–π stacking interactions. This competitive intercalation destabilizes the stacking interactions of pairs of PyA units, resulting in dissociation of the self-duplexes. This behavior, which is opposite to that of coralyne-induced self-duplex formation of natural oligodeoxyadenylates, was exploited to prepare new types of DNA modules that can be switched between two different duplex states.
|Number of pages||4|
|Publication status||Published - 2016 Jul 1|
- DNA disassembly
- molecular devices
ASJC Scopus subject areas