Abstract
The second-generation oral anticancer agent UFT is a combination of uracil, which has fluorouracil's (5-FU) degradation-inhibitory effect, and tegafur, which is slowly converted to 5-FU in vivo, and UFT shows a higher 5-FU concentration in the tumor tissues than is achieved by tegafur alone or with comparable doses of intravenous 5-FU. Mucocutaneous side reactions induced by UFT are rare and these include photosensitivity of the lichenoid and eczematous types, acral erythema, hyperpigmentation, palmoplantar keratoderma and scleroderma-like reactions, and discoid lupus erythematosus (DLE)-like eruption. However, there has been no report in the Korean medical literature on patients presenting with a DLE-like eruption associated with UFT. So, we report here a case of DLE-like eruption induced by oral UFT.
| Original language | English |
|---|---|
| Pages (from-to) | 1004-1007 |
| Number of pages | 4 |
| Journal | Korean Journal of Dermatology |
| Volume | 48 |
| Issue number | 11 |
| Publication status | Published - 2010 Nov 1 |
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Keywords
- Discoid lupus erythematosus
- Tegafur
- UFT
ASJC Scopus subject areas
- Dermatology
Cite this
Discoid lupus erythematosus-like eruption induced by tegafur - Uracil (UFT). / Yoon, Junghee; Seo, Soo-Hong; Kye, Young Chul; Ahn, Hyo Hyun.
In: Korean Journal of Dermatology, Vol. 48, No. 11, 01.11.2010, p. 1004-1007.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Discoid lupus erythematosus-like eruption induced by tegafur - Uracil (UFT)
AU - Yoon, Junghee
AU - Seo, Soo-Hong
AU - Kye, Young Chul
AU - Ahn, Hyo Hyun
PY - 2010/11/1
Y1 - 2010/11/1
N2 - The second-generation oral anticancer agent UFT is a combination of uracil, which has fluorouracil's (5-FU) degradation-inhibitory effect, and tegafur, which is slowly converted to 5-FU in vivo, and UFT shows a higher 5-FU concentration in the tumor tissues than is achieved by tegafur alone or with comparable doses of intravenous 5-FU. Mucocutaneous side reactions induced by UFT are rare and these include photosensitivity of the lichenoid and eczematous types, acral erythema, hyperpigmentation, palmoplantar keratoderma and scleroderma-like reactions, and discoid lupus erythematosus (DLE)-like eruption. However, there has been no report in the Korean medical literature on patients presenting with a DLE-like eruption associated with UFT. So, we report here a case of DLE-like eruption induced by oral UFT.
AB - The second-generation oral anticancer agent UFT is a combination of uracil, which has fluorouracil's (5-FU) degradation-inhibitory effect, and tegafur, which is slowly converted to 5-FU in vivo, and UFT shows a higher 5-FU concentration in the tumor tissues than is achieved by tegafur alone or with comparable doses of intravenous 5-FU. Mucocutaneous side reactions induced by UFT are rare and these include photosensitivity of the lichenoid and eczematous types, acral erythema, hyperpigmentation, palmoplantar keratoderma and scleroderma-like reactions, and discoid lupus erythematosus (DLE)-like eruption. However, there has been no report in the Korean medical literature on patients presenting with a DLE-like eruption associated with UFT. So, we report here a case of DLE-like eruption induced by oral UFT.
KW - Discoid lupus erythematosus
KW - Tegafur
KW - UFT
UR - http://www.scopus.com/inward/record.url?scp=79960909678&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960909678&partnerID=8YFLogxK
M3 - Article
VL - 48
SP - 1004
EP - 1007
JO - Korean Journal of Dermatology
JF - Korean Journal of Dermatology
SN - 0494-4739
IS - 11
ER -