Discoid lupus erythematosus-like eruption induced by tegafur - Uracil (UFT)

Research output: Contribution to journalArticle

Abstract

The second-generation oral anticancer agent UFT is a combination of uracil, which has fluorouracil's (5-FU) degradation-inhibitory effect, and tegafur, which is slowly converted to 5-FU in vivo, and UFT shows a higher 5-FU concentration in the tumor tissues than is achieved by tegafur alone or with comparable doses of intravenous 5-FU. Mucocutaneous side reactions induced by UFT are rare and these include photosensitivity of the lichenoid and eczematous types, acral erythema, hyperpigmentation, palmoplantar keratoderma and scleroderma-like reactions, and discoid lupus erythematosus (DLE)-like eruption. However, there has been no report in the Korean medical literature on patients presenting with a DLE-like eruption associated with UFT. So, we report here a case of DLE-like eruption induced by oral UFT.

Original languageEnglish
Pages (from-to)1004-1007
Number of pages4
JournalKorean Journal of Dermatology
Volume48
Issue number11
Publication statusPublished - 2010 Nov 1

Fingerprint

Discoid Lupus Erythematosus
Tegafur
Uracil
Fluorouracil
Palmoplantar Keratoderma
Hyperpigmentation
Erythema
Antineoplastic Agents
Extremities
Neoplasms

Keywords

  • Discoid lupus erythematosus
  • Tegafur
  • UFT

ASJC Scopus subject areas

  • Dermatology

Cite this

Discoid lupus erythematosus-like eruption induced by tegafur - Uracil (UFT). / Yoon, Junghee; Seo, Soo-Hong; Kye, Young Chul; Ahn, Hyo Hyun.

In: Korean Journal of Dermatology, Vol. 48, No. 11, 01.11.2010, p. 1004-1007.

Research output: Contribution to journalArticle

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