Discordant impairment of multidirectional myocardial deformation in rats with doxorubicin induced cardiomyopathy

Yong Hyun Kim, Mina Kim, Seong Mi Park, Seong Hwan Kim, Sang Yup Lim, Jeong Cheon Ahn, Woo Hyuk Song, Wan Joo Shim

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6 Citations (Scopus)

Abstract

Background: In doxorubicin-induced cardiomyopathy (DIC), the sequence of decrease in multidirectional myocardial deformation has not been clearly elucidated. Objectives: We investigated the sequence of myocardial deformations in rat DIC, using two-dimensional speckle tracking echocardiography (2DSTE). Methods: Twenty rats were treated with doxorubicin (1.25 mg/kg × 16 times, intraperitoneal) for 4 weeks and compared with nine control rats. Myocardial strain analysis with 2DSTE, as well as conventional echocardiography, was obtained. Results: Compared with baseline, longitudinal strain/strain rate (LS/LSr) decreased at week 2 (-15.7 ± 1.5 to -14.1 ± 1.4%, P = 0.01 for LS; -4.4 ± 0.7 to -3.9 ± 0.5 per second, P = 0.009 for LSr). Left ventricular ejection fraction (LVEF) and circumferential strain (CS) decreased at week 4 (80.3 ± 3.2 to 78.1 ± 3.3%, P = 0.031 for LVEF; -18.6 ± 1.9 to -15.0 ± 3.4%, P = 0.019 for CS). Circumferential strain rate (CSr) decreased at week 6 (-5.5 ± 0.8 to -4.6 ± 1.0 per second, P = 0.008). Radial strain/strain rate (RS/RSr) decreased at week 8 (54.8 ± 9.4 to 43.7 ± 10.6%, P = 0.005 for RS; 8.0 ± 1.1 to 7.0 ± 1.1 per second, P = 0.005 for RSr), while there was no significant change in LS/LSr, LVEF, CS/CSr, or RS/RSr in the control group. LVEF had the highest correlation with LS (r =-0.607, P = 0.000) and the lowest correlation with RSr (r = 0.357, P = 0.000). Conclusions: In DIC of rat hearts, LS/LSr decreased first, and then LVEF, CS, CSr, RS/RSr subsequently decreased. LS/LSr is considered to be a more sensitive predictor than LVEF in progressive rat DIC, and RS/RSr was preserved until the last stage. (Echocardiography 2012;29:720-728)

Original languageEnglish
Pages (from-to)720-728
Number of pages9
JournalEchocardiography
Volume29
Issue number6
DOIs
Publication statusPublished - 2012 Jul

Keywords

  • cardiomyopathy
  • left ventricular function
  • myocardial strain
  • two-dimensional speckle tracking echocardiography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Kim, Y. H., Kim, M., Park, S. M., Kim, S. H., Lim, S. Y., Ahn, J. C., Song, W. H., & Shim, W. J. (2012). Discordant impairment of multidirectional myocardial deformation in rats with doxorubicin induced cardiomyopathy. Echocardiography, 29(6), 720-728. https://doi.org/10.1111/j.1540-8175.2012.01689.x