Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects

Chung Ju, Sumi Song, Sunyoung Hwang, Chorong Kim, Minkyoung Kim, Jail Gu, Yu Kyoung Oh, Kyeong Lee, Jinsun Kwon, Kiho Lee, Won-Ki Kim, Yongseok Choi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A series of novel (1S)-(-)-verbenone derivatives was synthesized bearing a 4-styryl scaffold. The synthesized compounds were tested for their anti-oxidant, anti-excitotoxic, and anti-ischemic activities. These derivatives significantly reduced oxygen-glucose deprivation-induced neuronal injury and N-methyl-d-aspartic acid-evoked excitotoxicity in cortical neurons. Furthermore, compound 3f was identified as a potent anti-ischemic agent in an in vitro ischemic model, potentially due to the inhibition of N-methyl-d-aspartic acid-evoked excitotoxicity and oxidative/nitrosative stress.

Original languageEnglish
Pages (from-to)5421-5425
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number19
DOIs
Publication statusPublished - 2013 Oct 1

    Fingerprint

Keywords

  • Anti-excitotoxic activity
  • Anti-ischemic activity
  • Anti-oxidant activity
  • Cerebral ischemia
  • Verbenone

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this