Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects

Chung Ju, Sumi Song, Sunyoung Hwang, Chorong Kim, Minkyoung Kim, Jail Gu, Yu Kyoung Oh, Kyeong Lee, Jinsun Kwon, Kiho Lee, Won-Ki Kim, Yongseok Choi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A series of novel (1S)-(-)-verbenone derivatives was synthesized bearing a 4-styryl scaffold. The synthesized compounds were tested for their anti-oxidant, anti-excitotoxic, and anti-ischemic activities. These derivatives significantly reduced oxygen-glucose deprivation-induced neuronal injury and N-methyl-d-aspartic acid-evoked excitotoxicity in cortical neurons. Furthermore, compound 3f was identified as a potent anti-ischemic agent in an in vitro ischemic model, potentially due to the inhibition of N-methyl-d-aspartic acid-evoked excitotoxicity and oxidative/nitrosative stress.

Original languageEnglish
Pages (from-to)5421-5425
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number19
DOIs
Publication statusPublished - 2013 Oct 1

Fingerprint

Oxidants
Aspartic Acid
Bearings (structural)
Derivatives
Oxidative stress
Scaffolds
Neurons
Oxidative Stress
Oxygen
Glucose
Wounds and Injuries
verbenone
In Vitro Techniques

Keywords

  • Anti-excitotoxic activity
  • Anti-ischemic activity
  • Anti-oxidant activity
  • Cerebral ischemia
  • Verbenone

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects. / Ju, Chung; Song, Sumi; Hwang, Sunyoung; Kim, Chorong; Kim, Minkyoung; Gu, Jail; Oh, Yu Kyoung; Lee, Kyeong; Kwon, Jinsun; Lee, Kiho; Kim, Won-Ki; Choi, Yongseok.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 23, No. 19, 01.10.2013, p. 5421-5425.

Research output: Contribution to journalArticle

Ju, Chung ; Song, Sumi ; Hwang, Sunyoung ; Kim, Chorong ; Kim, Minkyoung ; Gu, Jail ; Oh, Yu Kyoung ; Lee, Kyeong ; Kwon, Jinsun ; Lee, Kiho ; Kim, Won-Ki ; Choi, Yongseok. / Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects. In: Bioorganic and Medicinal Chemistry Letters. 2013 ; Vol. 23, No. 19. pp. 5421-5425.
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