Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia: Assessment with serial CT

Thomas E. Hartman, Steven L. Primack, Eun-Young Kang, Stephen J. Swensen, David M. Hansell, Georgeann McGuinness, Nestor L. Müller

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Abstract

To determine the outcome of areas of ground-glass attenuation and assess disease progression on serial high-resolution CT (HRCT) scans of patients with biopsy specimen-proved usual interstitial pneumonia (UIP) and desquamative interstitial pneumonia (DIP). Materials and methods: Twelve patients with biopsy specimen-proved UIP and 11 patients with biopsy specimen-proved DIP who had initial and follow-up HBCT scans (median interval, 10 months) were reviewed. Eleven patients with UIP and 11 with DIP received treatment between the initial and follow-up CT scans. The scans were evaluated for the presence and extent of ground-glass attenuation, irregular linear opacities and honeycombing, and overall extent of parenchymal involvement. Results: On initial CT scans, all 12 patients with UIP had areas of ground-glass attenuation (mean ± SD extent, 30 ± 16%) and irregular lines (mean ± SD extent, 17 ± 7%) and 10 patients had honeycombing (mean ± SD extent, 10 ± 6%). All 11 patients with DIP had areas of ground-glass attenuation on initial HRCT scans (mean ± SD extent, 51 ± 26%), 5 patients had irregular linear opacities (mean ± SD extent, 5 ± 5%), and 1 patient had honeycombing. Nine of the 12 patients with UIP showed increase in the extent of ground-glass attenuation (n=6) or progression to irregular lines (n=2) or honeycombing (n=4) on follow-up as compared with only 2 patients with DIP who showed progression to irregular lines (n=1) or honeycombing (n=1) (p<0.01, χ2 test). Conclusion: In patients with UIP, areas of ground- glass attenuation usually increase in extent or progress to fibrosis despite treatment. Areas of ground-glass attenuation in most patients with DIP remain stable or improve with treatment.

Original languageEnglish
Pages (from-to)378-382
Number of pages5
JournalChest
Volume110
Issue number2
Publication statusPublished - 1996 Jan 1

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Keywords

  • computed tomography
  • desquamative interstitial pneumonia
  • disease progression
  • usual interstitial pneumonia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Hartman, T. E., Primack, S. L., Kang, E-Y., Swensen, S. J., Hansell, D. M., McGuinness, G., & Müller, N. L. (1996). Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia: Assessment with serial CT. Chest, 110(2), 378-382.