Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia

Assessment with serial CT

Thomas E. Hartman, Steven L. Primack, Eun-Young Kang, Stephen J. Swensen, David M. Hansell, Georgeann McGuinness, Nestor L. Müller

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

To determine the outcome of areas of ground-glass attenuation and assess disease progression on serial high-resolution CT (HRCT) scans of patients with biopsy specimen-proved usual interstitial pneumonia (UIP) and desquamative interstitial pneumonia (DIP). Materials and methods: Twelve patients with biopsy specimen-proved UIP and 11 patients with biopsy specimen-proved DIP who had initial and follow-up HBCT scans (median interval, 10 months) were reviewed. Eleven patients with UIP and 11 with DIP received treatment between the initial and follow-up CT scans. The scans were evaluated for the presence and extent of ground-glass attenuation, irregular linear opacities and honeycombing, and overall extent of parenchymal involvement. Results: On initial CT scans, all 12 patients with UIP had areas of ground-glass attenuation (mean ± SD extent, 30 ± 16%) and irregular lines (mean ± SD extent, 17 ± 7%) and 10 patients had honeycombing (mean ± SD extent, 10 ± 6%). All 11 patients with DIP had areas of ground-glass attenuation on initial HRCT scans (mean ± SD extent, 51 ± 26%), 5 patients had irregular linear opacities (mean ± SD extent, 5 ± 5%), and 1 patient had honeycombing. Nine of the 12 patients with UIP showed increase in the extent of ground-glass attenuation (n=6) or progression to irregular lines (n=2) or honeycombing (n=4) on follow-up as compared with only 2 patients with DIP who showed progression to irregular lines (n=1) or honeycombing (n=1) (p<0.01, χ2 test). Conclusion: In patients with UIP, areas of ground- glass attenuation usually increase in extent or progress to fibrosis despite treatment. Areas of ground-glass attenuation in most patients with DIP remain stable or improve with treatment.

Original languageEnglish
Pages (from-to)378-382
Number of pages5
JournalChest
Volume110
Issue number2
Publication statusPublished - 1996 Jan 1

Fingerprint

Idiopathic Pulmonary Fibrosis
Interstitial Lung Diseases
Disease Progression
Glass
Biopsy

Keywords

  • computed tomography
  • desquamative interstitial pneumonia
  • disease progression
  • usual interstitial pneumonia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Hartman, T. E., Primack, S. L., Kang, E-Y., Swensen, S. J., Hansell, D. M., McGuinness, G., & Müller, N. L. (1996). Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia: Assessment with serial CT. Chest, 110(2), 378-382.

Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia : Assessment with serial CT. / Hartman, Thomas E.; Primack, Steven L.; Kang, Eun-Young; Swensen, Stephen J.; Hansell, David M.; McGuinness, Georgeann; Müller, Nestor L.

In: Chest, Vol. 110, No. 2, 01.01.1996, p. 378-382.

Research output: Contribution to journalArticle

Hartman, TE, Primack, SL, Kang, E-Y, Swensen, SJ, Hansell, DM, McGuinness, G & Müller, NL 1996, 'Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia: Assessment with serial CT', Chest, vol. 110, no. 2, pp. 378-382.
Hartman TE, Primack SL, Kang E-Y, Swensen SJ, Hansell DM, McGuinness G et al. Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia: Assessment with serial CT. Chest. 1996 Jan 1;110(2):378-382.
Hartman, Thomas E. ; Primack, Steven L. ; Kang, Eun-Young ; Swensen, Stephen J. ; Hansell, David M. ; McGuinness, Georgeann ; Müller, Nestor L. / Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia : Assessment with serial CT. In: Chest. 1996 ; Vol. 110, No. 2. pp. 378-382.
@article{a299de0111184ba6a19d9d0f0cf49aa2,
title = "Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia: Assessment with serial CT",
abstract = "To determine the outcome of areas of ground-glass attenuation and assess disease progression on serial high-resolution CT (HRCT) scans of patients with biopsy specimen-proved usual interstitial pneumonia (UIP) and desquamative interstitial pneumonia (DIP). Materials and methods: Twelve patients with biopsy specimen-proved UIP and 11 patients with biopsy specimen-proved DIP who had initial and follow-up HBCT scans (median interval, 10 months) were reviewed. Eleven patients with UIP and 11 with DIP received treatment between the initial and follow-up CT scans. The scans were evaluated for the presence and extent of ground-glass attenuation, irregular linear opacities and honeycombing, and overall extent of parenchymal involvement. Results: On initial CT scans, all 12 patients with UIP had areas of ground-glass attenuation (mean ± SD extent, 30 ± 16{\%}) and irregular lines (mean ± SD extent, 17 ± 7{\%}) and 10 patients had honeycombing (mean ± SD extent, 10 ± 6{\%}). All 11 patients with DIP had areas of ground-glass attenuation on initial HRCT scans (mean ± SD extent, 51 ± 26{\%}), 5 patients had irregular linear opacities (mean ± SD extent, 5 ± 5{\%}), and 1 patient had honeycombing. Nine of the 12 patients with UIP showed increase in the extent of ground-glass attenuation (n=6) or progression to irregular lines (n=2) or honeycombing (n=4) on follow-up as compared with only 2 patients with DIP who showed progression to irregular lines (n=1) or honeycombing (n=1) (p<0.01, χ2 test). Conclusion: In patients with UIP, areas of ground- glass attenuation usually increase in extent or progress to fibrosis despite treatment. Areas of ground-glass attenuation in most patients with DIP remain stable or improve with treatment.",
keywords = "computed tomography, desquamative interstitial pneumonia, disease progression, usual interstitial pneumonia",
author = "Hartman, {Thomas E.} and Primack, {Steven L.} and Eun-Young Kang and Swensen, {Stephen J.} and Hansell, {David M.} and Georgeann McGuinness and M{\"u}ller, {Nestor L.}",
year = "1996",
month = "1",
day = "1",
language = "English",
volume = "110",
pages = "378--382",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "2",

}

TY - JOUR

T1 - Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia

T2 - Assessment with serial CT

AU - Hartman, Thomas E.

AU - Primack, Steven L.

AU - Kang, Eun-Young

AU - Swensen, Stephen J.

AU - Hansell, David M.

AU - McGuinness, Georgeann

AU - Müller, Nestor L.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - To determine the outcome of areas of ground-glass attenuation and assess disease progression on serial high-resolution CT (HRCT) scans of patients with biopsy specimen-proved usual interstitial pneumonia (UIP) and desquamative interstitial pneumonia (DIP). Materials and methods: Twelve patients with biopsy specimen-proved UIP and 11 patients with biopsy specimen-proved DIP who had initial and follow-up HBCT scans (median interval, 10 months) were reviewed. Eleven patients with UIP and 11 with DIP received treatment between the initial and follow-up CT scans. The scans were evaluated for the presence and extent of ground-glass attenuation, irregular linear opacities and honeycombing, and overall extent of parenchymal involvement. Results: On initial CT scans, all 12 patients with UIP had areas of ground-glass attenuation (mean ± SD extent, 30 ± 16%) and irregular lines (mean ± SD extent, 17 ± 7%) and 10 patients had honeycombing (mean ± SD extent, 10 ± 6%). All 11 patients with DIP had areas of ground-glass attenuation on initial HRCT scans (mean ± SD extent, 51 ± 26%), 5 patients had irregular linear opacities (mean ± SD extent, 5 ± 5%), and 1 patient had honeycombing. Nine of the 12 patients with UIP showed increase in the extent of ground-glass attenuation (n=6) or progression to irregular lines (n=2) or honeycombing (n=4) on follow-up as compared with only 2 patients with DIP who showed progression to irregular lines (n=1) or honeycombing (n=1) (p<0.01, χ2 test). Conclusion: In patients with UIP, areas of ground- glass attenuation usually increase in extent or progress to fibrosis despite treatment. Areas of ground-glass attenuation in most patients with DIP remain stable or improve with treatment.

AB - To determine the outcome of areas of ground-glass attenuation and assess disease progression on serial high-resolution CT (HRCT) scans of patients with biopsy specimen-proved usual interstitial pneumonia (UIP) and desquamative interstitial pneumonia (DIP). Materials and methods: Twelve patients with biopsy specimen-proved UIP and 11 patients with biopsy specimen-proved DIP who had initial and follow-up HBCT scans (median interval, 10 months) were reviewed. Eleven patients with UIP and 11 with DIP received treatment between the initial and follow-up CT scans. The scans were evaluated for the presence and extent of ground-glass attenuation, irregular linear opacities and honeycombing, and overall extent of parenchymal involvement. Results: On initial CT scans, all 12 patients with UIP had areas of ground-glass attenuation (mean ± SD extent, 30 ± 16%) and irregular lines (mean ± SD extent, 17 ± 7%) and 10 patients had honeycombing (mean ± SD extent, 10 ± 6%). All 11 patients with DIP had areas of ground-glass attenuation on initial HRCT scans (mean ± SD extent, 51 ± 26%), 5 patients had irregular linear opacities (mean ± SD extent, 5 ± 5%), and 1 patient had honeycombing. Nine of the 12 patients with UIP showed increase in the extent of ground-glass attenuation (n=6) or progression to irregular lines (n=2) or honeycombing (n=4) on follow-up as compared with only 2 patients with DIP who showed progression to irregular lines (n=1) or honeycombing (n=1) (p<0.01, χ2 test). Conclusion: In patients with UIP, areas of ground- glass attenuation usually increase in extent or progress to fibrosis despite treatment. Areas of ground-glass attenuation in most patients with DIP remain stable or improve with treatment.

KW - computed tomography

KW - desquamative interstitial pneumonia

KW - disease progression

KW - usual interstitial pneumonia

UR - http://www.scopus.com/inward/record.url?scp=0029738355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029738355&partnerID=8YFLogxK

M3 - Article

VL - 110

SP - 378

EP - 382

JO - Chest

JF - Chest

SN - 0012-3692

IS - 2

ER -