Disease research and drug development models based on genetically altered human embryonic stem cells.

Hoseok Song, Yang Xu

Research output: Contribution to journalArticle

Abstract

Mouse models have become an indispensable tool to study the pathogenesis of human diseases. However, due to the apparent cellular and physiological differences between mouse and human, mouse models often fail to faithfully recapitulate certain defects observed in human patients. In addition, these differences contribute to the dilemma in drug development that many therapeutic strategies work well in mouse models but do poorly in human patients. Therefore, it has become increasingly important to develop additional physiologically relevant human disease models for mechanistic studies and drug development. With the unlimited self-renewal capability and the pluripotency to differentiate into all cell types in the body, human embryonic stem cells (hESCs) with causative genetic mutations as well as their differentiated derivatives represent the much needed human disease models for studies on disease mechanisms and for drug development. Here we summarize recent progresses in developing hESCs into human disease models.

Original languageEnglish
Pages (from-to)500-503
Number of pages4
JournalDiscovery medicine
Volume9
Issue number49
Publication statusPublished - 2010 Jun
Externally publishedYes

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Research
Pharmaceutical Preparations
Human Embryonic Stem Cells
Mutation
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Disease research and drug development models based on genetically altered human embryonic stem cells. / Song, Hoseok; Xu, Yang.

In: Discovery medicine, Vol. 9, No. 49, 06.2010, p. 500-503.

Research output: Contribution to journalArticle

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