Disrupted brain functional network in internet addiction disorder: A resting-state functional magnetic resonance imaging study

Chong Yaw Wee, Zhimin Zhao, Pew Thian Yap, Guorong Wu, Feng Shi, True Price, Yasong Du, Jianrong Xu, Yan Zhou, Dinggang Shen

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Internet addiction disorder (IAD) is increasingly recognized as a mental health disorder, particularly among adolescents. The pathogenesis associated with IAD, however, remains unclear. In this study, we aim to explore the encephalic functional characteristics of IAD adolescents at rest using functional magnetic resonance imaging data. We adopted a graph-theoretic approach to investigate possible disruptions of functional connectivity in terms of network properties including small-worldness, efficiency, and nodal centrality on 17 adolescents with IAD and 16 socio-demographically matched healthy controls. False discovery rate-corrected parametric tests were performed to evaluate the statistical significance of grouplevel network topological differences. In addition, a correlation analysis was performed to assess the relationships between functional connectivity and clinical measures in the IAD group. Our results demonstrate that there is significant disruption in the functional connectome of IAD patients, particularly between regions located in the frontal, occipital, and parietal lobes. The affected connections are long-range and inter-hemispheric connections. Although significant alterations are observed for regional nodal metrics, there is no difference in global network topology between IAD and healthy groups. In addition, correlation analysis demonstrates that the observed regional abnormalities are correlated with the IAD severity and behavioral clinical assessments. Our findings, which are relatively consistent between anatomically and functionally defined atlases, suggest that IAD causes disruptions of functional connectivity and, importantly, that such disruptions might link to behavioral impairments.

Original languageEnglish
Article numbere107306
JournalPLoS One
Volume9
Issue number9
DOIs
Publication statusPublished - 2014 Sep 16

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magnetic resonance imaging
Internet
Brain
Magnetic Resonance Imaging
brain
Connectome
Occipital Lobe
Parietal Lobe
mental health
Atlases
Frontal Lobe
Mental Disorders
topology
functional properties
Mental Health
pathogenesis
Topology
Health

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Disrupted brain functional network in internet addiction disorder : A resting-state functional magnetic resonance imaging study. / Wee, Chong Yaw; Zhao, Zhimin; Yap, Pew Thian; Wu, Guorong; Shi, Feng; Price, True; Du, Yasong; Xu, Jianrong; Zhou, Yan; Shen, Dinggang.

In: PLoS One, Vol. 9, No. 9, e107306, 16.09.2014.

Research output: Contribution to journalArticle

Wee, Chong Yaw ; Zhao, Zhimin ; Yap, Pew Thian ; Wu, Guorong ; Shi, Feng ; Price, True ; Du, Yasong ; Xu, Jianrong ; Zhou, Yan ; Shen, Dinggang. / Disrupted brain functional network in internet addiction disorder : A resting-state functional magnetic resonance imaging study. In: PLoS One. 2014 ; Vol. 9, No. 9.
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