TY - JOUR
T1 - Disrupted functional connectome in antisocial personality disorder
AU - Jiang, Weixiong
AU - Shi, Feng
AU - Liao, Jian
AU - Liu, Huasheng
AU - Wang, Tao
AU - Shen, Celina
AU - Shen, Hui
AU - Hu, Dewen
AU - Wang, Wei
AU - Shen, Dinggang
N1 - Funding Information:
Acknowledgments We thank all the volunteers for their participation in the study and the anonymous referees for their insightful comments and suggestions. The Funding Project of Education Ministry for the Development of Liberal Arts and Social Sciences (13YJCZH068), the China Postdoctoral Science Foundation (2015 M582879) and Key Laboratory of Basic Education Information Technology of Hunan Province (2015TP1017) helped support this work. Additionally, this study was partially supported by the National Natural Science Foundation of China (61420106001, 61375111, 81571298) and, in part, supported by NIH grants (AG041721, EB006733, EB008374, EB009634).
Funding Information:
We thank all the volunteers for their participation in the study and the anonymous referees for their insightful comments and suggestions. The Funding Project of Education Ministry for the Development of Liberal Arts and Social Sciences (13YJCZH068), the China Postdoctoral Science Foundation (2015?M582879) and Key Laboratory of Basic Education Information Technology of Hunan Province (2015TP1017) helped support this work. Additionally, this study was partially supported by the National Natural Science Foundation of China (61420106001, 61375111, 81571298) and, in part, supported by NIH grants (AG041721, EB006733, EB008374, EB009634).
Publisher Copyright:
© 2016, Springer Science+Business Media New York.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Studies on antisocial personality disorder (ASPD) subjects focus on brain functional alterations in relation to antisocial behaviors. Neuroimaging research has identified a number of focal brain regions with abnormal structures or functions in ASPD. However, little is known about the connections among brain regions in terms of inter-regional whole-brain networks in ASPD patients, as well as possible alterations of brain functional topological organization. In this study, we employ resting-state functional magnetic resonance imaging (R-fMRI) to examine functional connectome of 32 ASPD patients and 35 normal controls by using a variety of network properties, including small-worldness, modularity, and connectivity. The small-world analysis reveals that ASPD patients have increased path length and decreased network efficiency, which implies a reduced ability of global integration of whole-brain functions. Modularity analysis suggests ASPD patients have decreased overall modularity, merged network modules, and reduced intra- and inter-module connectivities related to frontal regions. Also, network-based statistics show that an internal sub-network, composed of 16 nodes and 16 edges, is significantly affected in ASPD patients, where brain regions are mostly located in the fronto-parietal control network. These results suggest that ASPD is associated with both reduced brain integration and segregation in topological organization of functional brain networks, particularly in the fronto-parietal control network. These disruptions may contribute to disturbances in behavior and cognition in patients with ASPD. Our findings may provide insights into a deeper understanding of functional brain networks of ASPD.
AB - Studies on antisocial personality disorder (ASPD) subjects focus on brain functional alterations in relation to antisocial behaviors. Neuroimaging research has identified a number of focal brain regions with abnormal structures or functions in ASPD. However, little is known about the connections among brain regions in terms of inter-regional whole-brain networks in ASPD patients, as well as possible alterations of brain functional topological organization. In this study, we employ resting-state functional magnetic resonance imaging (R-fMRI) to examine functional connectome of 32 ASPD patients and 35 normal controls by using a variety of network properties, including small-worldness, modularity, and connectivity. The small-world analysis reveals that ASPD patients have increased path length and decreased network efficiency, which implies a reduced ability of global integration of whole-brain functions. Modularity analysis suggests ASPD patients have decreased overall modularity, merged network modules, and reduced intra- and inter-module connectivities related to frontal regions. Also, network-based statistics show that an internal sub-network, composed of 16 nodes and 16 edges, is significantly affected in ASPD patients, where brain regions are mostly located in the fronto-parietal control network. These results suggest that ASPD is associated with both reduced brain integration and segregation in topological organization of functional brain networks, particularly in the fronto-parietal control network. These disruptions may contribute to disturbances in behavior and cognition in patients with ASPD. Our findings may provide insights into a deeper understanding of functional brain networks of ASPD.
KW - Antisocial personality disorder
KW - Brain connectome
KW - Functional connectivity
KW - Modularity
KW - Topological organization
UR - http://www.scopus.com/inward/record.url?scp=84982286521&partnerID=8YFLogxK
U2 - 10.1007/s11682-016-9572-z
DO - 10.1007/s11682-016-9572-z
M3 - Article
C2 - 27541949
AN - SCOPUS:84982286521
VL - 11
SP - 1071
EP - 1084
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
SN - 1931-7557
IS - 4
ER -