Disrupted functional connectome in antisocial personality disorder

Weixiong Jiang, Feng Shi, Jian Liao, Huasheng Liu, Tao Wang, Celina Shen, Hui Shen, Dewen Hu, Wei Wang, Dinggang Shen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Studies on antisocial personality disorder (ASPD) subjects focus on brain functional alterations in relation to antisocial behaviors. Neuroimaging research has identified a number of focal brain regions with abnormal structures or functions in ASPD. However, little is known about the connections among brain regions in terms of inter-regional whole-brain networks in ASPD patients, as well as possible alterations of brain functional topological organization. In this study, we employ resting-state functional magnetic resonance imaging (R-fMRI) to examine functional connectome of 32 ASPD patients and 35 normal controls by using a variety of network properties, including small-worldness, modularity, and connectivity. The small-world analysis reveals that ASPD patients have increased path length and decreased network efficiency, which implies a reduced ability of global integration of whole-brain functions. Modularity analysis suggests ASPD patients have decreased overall modularity, merged network modules, and reduced intra- and inter-module connectivities related to frontal regions. Also, network-based statistics show that an internal sub-network, composed of 16 nodes and 16 edges, is significantly affected in ASPD patients, where brain regions are mostly located in the fronto-parietal control network. These results suggest that ASPD is associated with both reduced brain integration and segregation in topological organization of functional brain networks, particularly in the fronto-parietal control network. These disruptions may contribute to disturbances in behavior and cognition in patients with ASPD. Our findings may provide insights into a deeper understanding of functional brain networks of ASPD.

Original languageEnglish
Pages (from-to)1071-1084
Number of pages14
JournalBrain Imaging and Behavior
Volume11
Issue number4
DOIs
Publication statusPublished - 2017 Aug 1

Keywords

  • Antisocial personality disorder
  • Brain connectome
  • Functional connectivity
  • Modularity
  • Topological organization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

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  • Cite this

    Jiang, W., Shi, F., Liao, J., Liu, H., Wang, T., Shen, C., Shen, H., Hu, D., Wang, W., & Shen, D. (2017). Disrupted functional connectome in antisocial personality disorder. Brain Imaging and Behavior, 11(4), 1071-1084. https://doi.org/10.1007/s11682-016-9572-z