Disruption of dentate gyrus blocks effect of visual input on spatial firing of CA1 neurons

Jong Won Lee, Woon Ryoung Kim, Woong Sun, Min Whan Jung

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The role of dentate gyrus in hippocampal mnemonic processing is uncertain. One proposed role of dentate gyrus is binding internally generated spatial representation with sensory information on external landmarks. To test this hypothesis, we compared effects of visual input on spatial firing of CA1 neurons in Bax knock-out mice in which dentate gyrus neural circuitry is selectively disrupted. Whereas spatial selectivity of CA1 neuronal firing was significantly higher under normal illumination than complete darkness in wild-type mice, it was similarly low in both illumination conditions in Bax knock-out mice. Also, whereas the spatial location of neuronal firing was more stably maintained in the light than in the dark condition in wild-type mice, it was similarly unstable in both illumination conditions in Bax knock-out mice. These results show that visual input allows selective and stable spatial firing of CA1 neurons in normal animals, but this effect is lost if dentate gyrus neural circuitry is disrupted. Our results provide empirical support for the proposed role of dentate gyrus in aligning internally generated spatial representation to external landmarks in building a unified representation of external space.

Original languageEnglish
Pages (from-to)12999-13003
Number of pages5
JournalJournal of Neuroscience
Volume32
Issue number38
DOIs
Publication statusPublished - 2012 Sep 19

Fingerprint

Dentate Gyrus
Neurons
Lighting
Knockout Mice
Darkness
Light

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Disruption of dentate gyrus blocks effect of visual input on spatial firing of CA1 neurons. / Lee, Jong Won; Kim, Woon Ryoung; Sun, Woong; Jung, Min Whan.

In: Journal of Neuroscience, Vol. 32, No. 38, 19.09.2012, p. 12999-13003.

Research output: Contribution to journalArticle

Lee, Jong Won ; Kim, Woon Ryoung ; Sun, Woong ; Jung, Min Whan. / Disruption of dentate gyrus blocks effect of visual input on spatial firing of CA1 neurons. In: Journal of Neuroscience. 2012 ; Vol. 32, No. 38. pp. 12999-13003.
@article{e1f362bed2ee4879a139858368ad4a57,
title = "Disruption of dentate gyrus blocks effect of visual input on spatial firing of CA1 neurons",
abstract = "The role of dentate gyrus in hippocampal mnemonic processing is uncertain. One proposed role of dentate gyrus is binding internally generated spatial representation with sensory information on external landmarks. To test this hypothesis, we compared effects of visual input on spatial firing of CA1 neurons in Bax knock-out mice in which dentate gyrus neural circuitry is selectively disrupted. Whereas spatial selectivity of CA1 neuronal firing was significantly higher under normal illumination than complete darkness in wild-type mice, it was similarly low in both illumination conditions in Bax knock-out mice. Also, whereas the spatial location of neuronal firing was more stably maintained in the light than in the dark condition in wild-type mice, it was similarly unstable in both illumination conditions in Bax knock-out mice. These results show that visual input allows selective and stable spatial firing of CA1 neurons in normal animals, but this effect is lost if dentate gyrus neural circuitry is disrupted. Our results provide empirical support for the proposed role of dentate gyrus in aligning internally generated spatial representation to external landmarks in building a unified representation of external space.",
author = "Lee, {Jong Won} and Kim, {Woon Ryoung} and Woong Sun and Jung, {Min Whan}",
year = "2012",
month = "9",
day = "19",
doi = "10.1523/JNEUROSCI.2608-12.2012",
language = "English",
volume = "32",
pages = "12999--13003",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "38",

}

TY - JOUR

T1 - Disruption of dentate gyrus blocks effect of visual input on spatial firing of CA1 neurons

AU - Lee, Jong Won

AU - Kim, Woon Ryoung

AU - Sun, Woong

AU - Jung, Min Whan

PY - 2012/9/19

Y1 - 2012/9/19

N2 - The role of dentate gyrus in hippocampal mnemonic processing is uncertain. One proposed role of dentate gyrus is binding internally generated spatial representation with sensory information on external landmarks. To test this hypothesis, we compared effects of visual input on spatial firing of CA1 neurons in Bax knock-out mice in which dentate gyrus neural circuitry is selectively disrupted. Whereas spatial selectivity of CA1 neuronal firing was significantly higher under normal illumination than complete darkness in wild-type mice, it was similarly low in both illumination conditions in Bax knock-out mice. Also, whereas the spatial location of neuronal firing was more stably maintained in the light than in the dark condition in wild-type mice, it was similarly unstable in both illumination conditions in Bax knock-out mice. These results show that visual input allows selective and stable spatial firing of CA1 neurons in normal animals, but this effect is lost if dentate gyrus neural circuitry is disrupted. Our results provide empirical support for the proposed role of dentate gyrus in aligning internally generated spatial representation to external landmarks in building a unified representation of external space.

AB - The role of dentate gyrus in hippocampal mnemonic processing is uncertain. One proposed role of dentate gyrus is binding internally generated spatial representation with sensory information on external landmarks. To test this hypothesis, we compared effects of visual input on spatial firing of CA1 neurons in Bax knock-out mice in which dentate gyrus neural circuitry is selectively disrupted. Whereas spatial selectivity of CA1 neuronal firing was significantly higher under normal illumination than complete darkness in wild-type mice, it was similarly low in both illumination conditions in Bax knock-out mice. Also, whereas the spatial location of neuronal firing was more stably maintained in the light than in the dark condition in wild-type mice, it was similarly unstable in both illumination conditions in Bax knock-out mice. These results show that visual input allows selective and stable spatial firing of CA1 neurons in normal animals, but this effect is lost if dentate gyrus neural circuitry is disrupted. Our results provide empirical support for the proposed role of dentate gyrus in aligning internally generated spatial representation to external landmarks in building a unified representation of external space.

UR - http://www.scopus.com/inward/record.url?scp=84866423017&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866423017&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.2608-12.2012

DO - 10.1523/JNEUROSCI.2608-12.2012

M3 - Article

C2 - 22993417

AN - SCOPUS:84866423017

VL - 32

SP - 12999

EP - 13003

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 38

ER -