Disruptions in resting state functional connectivity in euthymic bipolar patients with insomnia symptoms

Ho Kyoung Yoon; Sheena I. Dev; Ashley N. Sutherland; Lisa T. Eyler

doi:10.1016/j.pscychresns.2018.03.005

Disruptions in resting state functional connectivity in euthymic bipolar patients with insomnia symptoms

Ho Kyoung Yoon, Sheena I. Dev, Ashley N. Sutherland, Lisa T. Eyler

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Insomnia is prevalent in bipolar disorder (BD) even during periods of euthymic mood. We compared resting state brain activity and cognitive function between euthymic BD with and without insomnia, and secondarily to healthy individuals. BD patients with insomnia symptoms showed a significantly lower functional connectivity within the task-positive network, compared to those without insomnia. They also showed significantly slower cognitive processing speed. These two features of BD with insomnia appeared relatively independent of each other. Preliminary findings suggest that exploration of the mechanisms of sleep disturbance in BD could lead to improved understanding and treatment of inattention in BD.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Psychiatry Research - Neuroimaging
Volume	275
DOIs	https://doi.org/10.1016/j.pscychresns.2018.03.005
Publication status	Published - 2018 May 30

Keywords

Bipolar disorder
Insomnia
Resting state

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.pscychresns.2018.03.005

Cite this

@article{24542d081d28453da20f67ab1b610f4f,

title = "Disruptions in resting state functional connectivity in euthymic bipolar patients with insomnia symptoms",

abstract = "Insomnia is prevalent in bipolar disorder (BD) even during periods of euthymic mood. We compared resting state brain activity and cognitive function between euthymic BD with and without insomnia, and secondarily to healthy individuals. BD patients with insomnia symptoms showed a significantly lower functional connectivity within the task-positive network, compared to those without insomnia. They also showed significantly slower cognitive processing speed. These two features of BD with insomnia appeared relatively independent of each other. Preliminary findings suggest that exploration of the mechanisms of sleep disturbance in BD could lead to improved understanding and treatment of inattention in BD.",

keywords = "Bipolar disorder, Insomnia, Resting state",

author = "Yoon, {Ho Kyoung} and Dev, {Sheena I.} and Sutherland, {Ashley N.} and Eyler, {Lisa T.}",

note = "Funding Information: This research was supported by the National Institutes of Health (NIH) grant MH083968 . Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2018",

month = may,

day = "30",

doi = "10.1016/j.pscychresns.2018.03.005",

language = "English",

volume = "275",

pages = "1--4",

journal = "Psychiatry Research - Neuroimaging",

issn = "0925-4927",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Disruptions in resting state functional connectivity in euthymic bipolar patients with insomnia symptoms

AU - Yoon, Ho Kyoung

AU - Dev, Sheena I.

AU - Sutherland, Ashley N.

AU - Eyler, Lisa T.

PY - 2018/5/30

Y1 - 2018/5/30

N2 - Insomnia is prevalent in bipolar disorder (BD) even during periods of euthymic mood. We compared resting state brain activity and cognitive function between euthymic BD with and without insomnia, and secondarily to healthy individuals. BD patients with insomnia symptoms showed a significantly lower functional connectivity within the task-positive network, compared to those without insomnia. They also showed significantly slower cognitive processing speed. These two features of BD with insomnia appeared relatively independent of each other. Preliminary findings suggest that exploration of the mechanisms of sleep disturbance in BD could lead to improved understanding and treatment of inattention in BD.

AB - Insomnia is prevalent in bipolar disorder (BD) even during periods of euthymic mood. We compared resting state brain activity and cognitive function between euthymic BD with and without insomnia, and secondarily to healthy individuals. BD patients with insomnia symptoms showed a significantly lower functional connectivity within the task-positive network, compared to those without insomnia. They also showed significantly slower cognitive processing speed. These two features of BD with insomnia appeared relatively independent of each other. Preliminary findings suggest that exploration of the mechanisms of sleep disturbance in BD could lead to improved understanding and treatment of inattention in BD.

KW - Bipolar disorder

KW - Insomnia

KW - Resting state

UR - http://www.scopus.com/inward/record.url?scp=85044136322&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2018.03.005

DO - 10.1016/j.pscychresns.2018.03.005

M3 - Article

C2 - 29572076

AN - SCOPUS:85044136322

SN - 0925-4927

VL - 275

SP - 1

EP - 4

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

ER -

Disruptions in resting state functional connectivity in euthymic bipolar patients with insomnia symptoms

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this