Dissecting the role of bone marrow stromal cells on bone metastases

Denise Buenrostro, Serkin Park, Julie A. Sterling

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Tumor-induced bone disease is a dynamic process that involves interactions with many cell types. Once metastatic cancer cells reach the bone, they are in contact with many different cell types that are present in the cell-rich bone marrow. These cells include the immune cells, myeloid cells, fibroblasts, osteoblasts, osteoclasts, and mesenchymal stem cells. Each of these cell populations can influence the behavior or gene expression of both the tumor cells and the bone microenvironment. Additionally, the tumor itself can alter the behavior of these bone marrow cells which further alters both the microenvironment and the tumor cells. While many groups focus on studying these interactions, much remains unknown. A better understanding of the interactions between the tumor cells and the bone microenvironment will improve our knowledge on how tumors establish in bone and may lead to improvements in diagnosing and treating bone metastases. This review details our current knowledge on the interactions between tumor cells that reside in bone and their microenvironment.

Original languageEnglish
Article number875305
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

Fingerprint

Mesenchymal Stromal Cells
Bone
Neoplasm Metastasis
Tumors
Bone and Bones
Cells
Cellular Microenvironment
Neoplasms
Bone Marrow Cells
Tumor Microenvironment
Bone Diseases
Osteoclasts
Myeloid Cells
Focus Groups
Osteoblasts
Fibroblasts
Stem cells
Gene expression
Gene Expression
Population

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Dissecting the role of bone marrow stromal cells on bone metastases. / Buenrostro, Denise; Park, Serkin; Sterling, Julie A.

In: BioMed Research International, Vol. 2014, 875305, 01.01.2014.

Research output: Contribution to journalReview article

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