Dissolution profile analysis of hydroxypropyl methylcellulose-based vitamin c tablets

Ja Hyun Cha; Jun Kee Hong; Sung Wan Lee; Jae Uk Cha; Won Hwa Ko; Hyon Ho Back; Hyun Jin Park

doi:10.9721/KJFST.2012.44.3.274

Dissolution profile analysis of hydroxypropyl methylcellulose-based vitamin c tablets

Ja Hyun Cha, Jun Kee Hong, Sung Wan Lee, Jae Uk Cha, Won Hwa Ko, Hyon Ho Back, Hyun Jin Park

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The objective of this study was to develop oral matrix tablets for the sustained release of vitamin C. In this study hydroxypropyl methylcellulose (HPMC) has been utilized as an excipient, as it is one of the most widely used polymers, for use during long periods of time in formations. The vitamin C tablet formulation depends on the molecular weight and concentration of sustained-delivery in HPMC. Anti-oxidants have been added as a dissolution medium in order to prevent vitamin C degradation in water. The dissolution test was carried out in a distilled water medium, and the release model equation was applied to analyze the vitamin C release pattern. The results demonstrated that the release and lasting power of vitamin C tablets, containing HPMC, lasted for more than 12 h.

Original language	English
Pages (from-to)	274-279
Number of pages	6
Journal	Korean Journal of Food Science and Technology
Volume	44
Issue number	3
DOIs	https://doi.org/10.9721/KJFST.2012.44.3.274
Publication status	Published - 2012

Keywords

HPMC
Hydroxypropyl methylcellulose
Matrix tablet
Sustained release
Vitamin C

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology

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10.9721/KJFST.2012.44.3.274

Cite this

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abstract = "The objective of this study was to develop oral matrix tablets for the sustained release of vitamin C. In this study hydroxypropyl methylcellulose (HPMC) has been utilized as an excipient, as it is one of the most widely used polymers, for use during long periods of time in formations. The vitamin C tablet formulation depends on the molecular weight and concentration of sustained-delivery in HPMC. Anti-oxidants have been added as a dissolution medium in order to prevent vitamin C degradation in water. The dissolution test was carried out in a distilled water medium, and the release model equation was applied to analyze the vitamin C release pattern. The results demonstrated that the release and lasting power of vitamin C tablets, containing HPMC, lasted for more than 12 h.",

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AU - Hong, Jun Kee

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AU - Cha, Jae Uk

AU - Ko, Won Hwa

AU - Back, Hyon Ho

AU - Park, Hyun Jin

PY - 2012

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AB - The objective of this study was to develop oral matrix tablets for the sustained release of vitamin C. In this study hydroxypropyl methylcellulose (HPMC) has been utilized as an excipient, as it is one of the most widely used polymers, for use during long periods of time in formations. The vitamin C tablet formulation depends on the molecular weight and concentration of sustained-delivery in HPMC. Anti-oxidants have been added as a dissolution medium in order to prevent vitamin C degradation in water. The dissolution test was carried out in a distilled water medium, and the release model equation was applied to analyze the vitamin C release pattern. The results demonstrated that the release and lasting power of vitamin C tablets, containing HPMC, lasted for more than 12 h.

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Dissolution profile analysis of hydroxypropyl methylcellulose-based vitamin c tablets

Abstract

Keywords

ASJC Scopus subject areas

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