Dissolution profile analysis of hydroxypropyl methylcellulose-based vitamin c tablets

Ja Hyun Cha, Jun Kee Hong, Sung Wan Lee, Jae Uk Cha, Won Hwa Ko, Hyon Ho Back, Hyun Jin Park

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The objective of this study was to develop oral matrix tablets for the sustained release of vitamin C. In this study hydroxypropyl methylcellulose (HPMC) has been utilized as an excipient, as it is one of the most widely used polymers, for use during long periods of time in formations. The vitamin C tablet formulation depends on the molecular weight and concentration of sustained-delivery in HPMC. Anti-oxidants have been added as a dissolution medium in order to prevent vitamin C degradation in water. The dissolution test was carried out in a distilled water medium, and the release model equation was applied to analyze the vitamin C release pattern. The results demonstrated that the release and lasting power of vitamin C tablets, containing HPMC, lasted for more than 12 h.

Original languageEnglish
Pages (from-to)274-279
Number of pages6
JournalKorean Journal of Food Science and Technology
Volume44
Issue number3
Publication statusPublished - 2012 Aug 6

Fingerprint

methylcellulose
Vitamins
Tablets
Ascorbic Acid
vitamins
ascorbic acid
Water
Excipients
Oxidants
oxidants
mouth
polymers
Polymers
water
Molecular Weight
Hypromellose Derivatives
molecular weight
degradation
testing

Keywords

  • HPMC
  • Hydroxypropyl methylcellulose
  • Matrix tablet
  • Sustained release
  • Vitamin C

ASJC Scopus subject areas

  • Food Science
  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Cha, J. H., Hong, J. K., Lee, S. W., Cha, J. U., Ko, W. H., Back, H. H., & Park, H. J. (2012). Dissolution profile analysis of hydroxypropyl methylcellulose-based vitamin c tablets. Korean Journal of Food Science and Technology, 44(3), 274-279.

Dissolution profile analysis of hydroxypropyl methylcellulose-based vitamin c tablets. / Cha, Ja Hyun; Hong, Jun Kee; Lee, Sung Wan; Cha, Jae Uk; Ko, Won Hwa; Back, Hyon Ho; Park, Hyun Jin.

In: Korean Journal of Food Science and Technology, Vol. 44, No. 3, 06.08.2012, p. 274-279.

Research output: Contribution to journalArticle

Cha, JH, Hong, JK, Lee, SW, Cha, JU, Ko, WH, Back, HH & Park, HJ 2012, 'Dissolution profile analysis of hydroxypropyl methylcellulose-based vitamin c tablets', Korean Journal of Food Science and Technology, vol. 44, no. 3, pp. 274-279.
Cha, Ja Hyun ; Hong, Jun Kee ; Lee, Sung Wan ; Cha, Jae Uk ; Ko, Won Hwa ; Back, Hyon Ho ; Park, Hyun Jin. / Dissolution profile analysis of hydroxypropyl methylcellulose-based vitamin c tablets. In: Korean Journal of Food Science and Technology. 2012 ; Vol. 44, No. 3. pp. 274-279.
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