Distal coronary embolization following acute myocardial infarction increases early infarct size and late left ventricular wall thinning in a porcine model

Reuben M. Thomas, Sang Yup Lim, Beiping Qiang, Azriel B. Osherov, Nilesh R. Ghugre, Hossein Noyan, Xiuling Qi, Rafael Wolff, Michelle Ladouceur-Wodzak, Thomas A. Berk, Jagdish Butany, Mansoor Husain, Graham A. Wright, Bradley H. Strauss

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    Background: Distal coronary embolization (DCE) of thrombotic material occurs frequently during percutaneous interventions for acute myocardial infarction and can alter coronary flow grades. The significance of DCE on infarct size and myocardial function remains unsettled. The aims of this study were to evaluate the effects of DCE sufficient to cause no-reflow on infarct size, cardiac function and ventricular remodeling in a porcine acute myocardial infarction model. Methods and results: Female Yorkshire pigs underwent 60 min balloon occlusion of the left anterior descending coronary artery followed by reperfusion and injection of either microthrombi (prepared from autologous porcine blood) sufficient to cause no-reflow (DCE), or saline (control). Animals were sacrificed at 3 h (n = 5), 3 days (n = 20) or 6 weeks (n = 20) post-AMI. Cardiovascular magnetic resonance (CMR), serum troponin-I, and cardiac gelatinase (MMP) and survival kinase (Akt) activities were assessed. At 3d, DCE increased infarct size (CMR: 18.8 % vs. 14.5 %, p = 0.04; serum troponin-I: 13.3 vs. 6.9 ng/uL, p < 0.05) and MMP-2 activity levels (0.81 vs. 0.49, p = 0.002), with reduced activation of Akt (0.06 versus 0.26, p = 0.02). At 6 weeks, there were no differences in infarct size, ventricular volume or ejection fraction between the two groups, although infarct transmurality (70 % vs. 57 %, p< 0.04) and ventricular thinning (percent change in mid anteroseptal wall thickness:-25.6 % vs. 0.7 %, p = 0.03) were significantly increased in the DCE group. Conclusions: DCE increased early infarct size, but without affecting later infarct size, cardiac function or ventricular volumes. The significance of the later remodelling changes (ventricular thinning and transmurality) following DCE, possibly due to changes in MMP-2 activity and Akt activation, merits further study.

    Original languageEnglish
    Article number106
    JournalJournal of Cardiovascular Magnetic Resonance
    Volume17
    Issue number1
    DOIs
    Publication statusPublished - 2015 Dec 1

    Keywords

    • Angioplasty
    • Cardiovascular magnetic resonance
    • Myocardial infarction
    • No reflow

    ASJC Scopus subject areas

    • Radiological and Ultrasound Technology
    • Radiology Nuclear Medicine and imaging
    • Cardiology and Cardiovascular Medicine

    Fingerprint

    Dive into the research topics of 'Distal coronary embolization following acute myocardial infarction increases early infarct size and late left ventricular wall thinning in a porcine model'. Together they form a unique fingerprint.

    Cite this