Distinct amyloid distribution patterns in amyloid positive subcortical vascular cognitive impairment

Hyemin Jang, Jong Yun Park, Young Kyoung Jang, Hee Jin Kim, Jin San Lee, Duk L. Na, Young Noh, Samuel N. Lockhart, Jun Kyung Seong, Sang Won Seo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Amyloid-β (Aβ) and cerebral small vessel disease (CSVD) commonly coexist. They can occur independently by chance, or may interact with each other. We aimed to determine whether the distribution of Aβ in subcortical vascular cognitive impairments (SVCI) patients can be classified by the underlying pathobiologies. A total of 45 11C-Pittsburgh compound B PET positive (PiB(+)) SVCI patients were included in this study. They were classified using a new cluster analysis method which adopted the Louvain method, which finds optimal decomposition of the participants based on similarity of relative Aβ deposition pattern. We measured atherosclerotic cerebral small vessel disease (CSVD) markers and cerebral amyloid angiopathy (CAA) markers. Forty-five PiB(+) SVCI patients were classified into two groups: 17 patients with the characteristic Alzheimer’s disease like Aβ uptake with sparing of occipital region (OccSp) and 28 patients with occipital predominant Aβ uptake (OccP). Compared to OccSp group, OccP group had more postive association of atherosclerotic CSVD score (p for interaction = 0.044), but not CAA score with occipital/global ratio of PiB uptake. Our findings suggested that Aβ positive SVCI patients might consist of heterogeneous groups with combined CSVD and Aβ resulting from various pathobiologies. Furthermore, atherosclerotic CSVD might explain increased occipital Aβ uptakes.

Original languageEnglish
Article number16178
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

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Cerebral Small Vessel Diseases
Amyloid
Blood Vessels
Cerebral Amyloid Angiopathy
Occipital Lobe
Cluster Analysis
Cognitive Dysfunction
Alzheimer Disease

ASJC Scopus subject areas

  • General

Cite this

Jang, H., Park, J. Y., Jang, Y. K., Kim, H. J., Lee, J. S., Na, D. L., ... Seo, S. W. (2018). Distinct amyloid distribution patterns in amyloid positive subcortical vascular cognitive impairment. Scientific Reports, 8(1), [16178]. https://doi.org/10.1038/s41598-018-34032-3

Distinct amyloid distribution patterns in amyloid positive subcortical vascular cognitive impairment. / Jang, Hyemin; Park, Jong Yun; Jang, Young Kyoung; Kim, Hee Jin; Lee, Jin San; Na, Duk L.; Noh, Young; Lockhart, Samuel N.; Seong, Jun Kyung; Seo, Sang Won.

In: Scientific Reports, Vol. 8, No. 1, 16178, 01.12.2018.

Research output: Contribution to journalArticle

Jang, H, Park, JY, Jang, YK, Kim, HJ, Lee, JS, Na, DL, Noh, Y, Lockhart, SN, Seong, JK & Seo, SW 2018, 'Distinct amyloid distribution patterns in amyloid positive subcortical vascular cognitive impairment', Scientific Reports, vol. 8, no. 1, 16178. https://doi.org/10.1038/s41598-018-34032-3
Jang, Hyemin ; Park, Jong Yun ; Jang, Young Kyoung ; Kim, Hee Jin ; Lee, Jin San ; Na, Duk L. ; Noh, Young ; Lockhart, Samuel N. ; Seong, Jun Kyung ; Seo, Sang Won. / Distinct amyloid distribution patterns in amyloid positive subcortical vascular cognitive impairment. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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