Distinct molecular evolution of influenza H3N2 strains in the 2016/17 season and its implications for vaccine effectiveness

Jin Il Kim, Sehee Park, Hyuk Chu, Ilseob Lee, Joon Yong Bae, Kirim Yoo, Juwon Kim, Joo Yeon Lee, Namju Lee, Miseon Kim, Jun Sub Kim, Kyung Wook Hong, Kyung Ran Jun, Jeong Nyeo Lee, Kisoon Kim, Man-Seong Park

Research output: Contribution to journalArticle

Abstract

Influenza virus is a respiratory pathogen that causes seasonal epidemics by resulting in a considerable number of influenza-like illness (ILI) patients. During the 2016/17 season, ILI rates increased unusually earlier and higher than previous seasons in Korea, and most viral isolates were subtyped as H3N2 strains. Notably, the hemagglutinin (HA) of most Korean H3N2 strains retained newly introduced lysine signatures in HA antigenic sites A and D, compared with that of clade 3C.2a vaccine virus, which affected antigenic distances to the standard vaccine antisera in a hemagglutination inhibition assay. The neuraminidase (NA) of Korean H3N2 strains also harbored amino acid mutations. However, neither consistent amino acid mutations nor common phylogenetic clustering patterns were observed. These suggest that Korean H3N2 strains of the 2016/17 season might be distantly related with the vaccine virus both in genotypic and phenotypic classifications, which would adversely affect vaccine effectiveness.

LanguageEnglish
Pages29-34
Number of pages6
JournalMolecular Phylogenetics and Evolution
Volume131
DOIs
Publication statusPublished - 2019 Feb 1

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influenza
Molecular Evolution
vaccine
Human Influenza
Vaccines
vaccines
virus
Hemagglutinins
hemagglutinins
mutation
amino acid
Viruses
Amino Acids
viruses
hemagglutination inhibition test
Mutation
amino acids
sialidase
Hemagglutination
Neuraminidase

Keywords

  • Hemagglutinin
  • Influenza
  • Molecular evolution
  • Neuraminidase
  • Vaccine effectiveness

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Cite this

Distinct molecular evolution of influenza H3N2 strains in the 2016/17 season and its implications for vaccine effectiveness. / Kim, Jin Il; Park, Sehee; Chu, Hyuk; Lee, Ilseob; Bae, Joon Yong; Yoo, Kirim; Kim, Juwon; Lee, Joo Yeon; Lee, Namju; Kim, Miseon; Kim, Jun Sub; Hong, Kyung Wook; Jun, Kyung Ran; Lee, Jeong Nyeo; Kim, Kisoon; Park, Man-Seong.

In: Molecular Phylogenetics and Evolution, Vol. 131, 01.02.2019, p. 29-34.

Research output: Contribution to journalArticle

Kim, JI, Park, S, Chu, H, Lee, I, Bae, JY, Yoo, K, Kim, J, Lee, JY, Lee, N, Kim, M, Kim, JS, Hong, KW, Jun, KR, Lee, JN, Kim, K & Park, M-S 2019, 'Distinct molecular evolution of influenza H3N2 strains in the 2016/17 season and its implications for vaccine effectiveness' Molecular Phylogenetics and Evolution, vol. 131, pp. 29-34. https://doi.org/10.1016/j.ympev.2018.10.042
Kim, Jin Il ; Park, Sehee ; Chu, Hyuk ; Lee, Ilseob ; Bae, Joon Yong ; Yoo, Kirim ; Kim, Juwon ; Lee, Joo Yeon ; Lee, Namju ; Kim, Miseon ; Kim, Jun Sub ; Hong, Kyung Wook ; Jun, Kyung Ran ; Lee, Jeong Nyeo ; Kim, Kisoon ; Park, Man-Seong. / Distinct molecular evolution of influenza H3N2 strains in the 2016/17 season and its implications for vaccine effectiveness. In: Molecular Phylogenetics and Evolution. 2019 ; Vol. 131. pp. 29-34.
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