Distributed rhythm generators underlie Caenorhabditis elegans forward locomotion

Anthony D. Fouad, Shelly Teng, Julian R. Mark, Alice Liu, Pilar Alvarez-Illera, Hongfei Ji, Angelica Du, Priya D. Bhirgoo, Eli Cornblath, Sihui Asuka Guan, Christopher Fang-Yen

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Coordinated rhythmic movements are ubiquitous in animal behavior. In many organisms, chains of neural oscillators underlie the generation of these rhythms. In C. elegans, locomotor wave generation has been poorly understood; in particular, it is unclear where in the circuit rhythms are generated, and whether there exists more than one such generator. We used optogenetic and ablation experiments to probe the nature of rhythm generation in the locomotor circuit. We found that multiple sections of forward locomotor circuitry are capable of independently generating rhythms. By perturbing different components of the motor circuit, we localize the source of secondary rhythms to cholinergic motor neurons in the midbody. Using rhythmic optogenetic perturbation, we demonstrate bidirectional entrainment of oscillations between different body regions. These results show that, as in many other vertebrates and invertebrates, the C. elegans motor circuit contains multiple oscillators that coordinate activity to generate behavior.

Original languageEnglish
Article numbere29913
JournaleLife
Volume7
DOIs
Publication statusPublished - 2018 Jan 23

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Fouad, A. D., Teng, S., Mark, J. R., Liu, A., Alvarez-Illera, P., Ji, H., Du, A., Bhirgoo, P. D., Cornblath, E., Guan, S. A., & Fang-Yen, C. (2018). Distributed rhythm generators underlie Caenorhabditis elegans forward locomotion. eLife, 7, [e29913]. https://doi.org/10.7554/eLife.29913