Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects

Jing Xu, Shen Li, Xiaocong Sun, Jun Ma, Feng Liu, Ling Tong, Dongho Lee, Yasushi Ohizumi, Muhetaer Tuerhong, Yuanqiang Guo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A phytochemical investigation of the leaves of Callicarpa kwangtungensis led to the isolation of three new diterpenoids (1–3), callipenes A–C, and eleven known analogues (4–14). Their structures were established on the basis of extensive analysis of NMR spectroscopic data, X-ray diffraction data, and experimental and calculated electronic circular dichroism spectra. Compounds 1 and 2 are rare abietane diterpenoids possessing a peroxide bridge. All of the isolates were found to inhibit LPS-induced NO production in BV-2 cells.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalFitoterapia
Volume113
DOIs
Publication statusPublished - 2016 Sep 1

Keywords

  • Abietane diterpenoids
  • Callicarpa kwangtungensis
  • Diterpenoids
  • NO inhibitory effects
  • TDDFT ECD calculations

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology
  • Drug Discovery

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    Xu, J., Li, S., Sun, X., Ma, J., Liu, F., Tong, L., Lee, D., Ohizumi, Y., Tuerhong, M., & Guo, Y. (2016). Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects. Fitoterapia, 113, 151-157. https://doi.org/10.1016/j.fitote.2016.07.012