Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects

Jing Xu, Shen Li, Xiaocong Sun, Jun Ma, Feng Liu, Ling Tong, Dongho Lee, Yasushi Ohizumi, Muhetaer Tuerhong, Yuanqiang Guo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A phytochemical investigation of the leaves of Callicarpa kwangtungensis led to the isolation of three new diterpenoids (1–3), callipenes A–C, and eleven known analogues (4–14). Their structures were established on the basis of extensive analysis of NMR spectroscopic data, X-ray diffraction data, and experimental and calculated electronic circular dichroism spectra. Compounds 1 and 2 are rare abietane diterpenoids possessing a peroxide bridge. All of the isolates were found to inhibit LPS-induced NO production in BV-2 cells.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalFitoterapia
Volume113
DOIs
Publication statusPublished - 2016 Sep 1

Fingerprint

Callicarpa
Diterpenes
Abietane Diterpenes
Peroxides
Phytochemicals
Circular Dichroism
X-Ray Diffraction

Keywords

  • Abietane diterpenoids
  • Callicarpa kwangtungensis
  • Diterpenoids
  • NO inhibitory effects
  • TDDFT ECD calculations

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology
  • Drug Discovery

Cite this

Xu, J., Li, S., Sun, X., Ma, J., Liu, F., Tong, L., ... Guo, Y. (2016). Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects. Fitoterapia, 113, 151-157. https://doi.org/10.1016/j.fitote.2016.07.012

Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects. / Xu, Jing; Li, Shen; Sun, Xiaocong; Ma, Jun; Liu, Feng; Tong, Ling; Lee, Dongho; Ohizumi, Yasushi; Tuerhong, Muhetaer; Guo, Yuanqiang.

In: Fitoterapia, Vol. 113, 01.09.2016, p. 151-157.

Research output: Contribution to journalArticle

Xu, J, Li, S, Sun, X, Ma, J, Liu, F, Tong, L, Lee, D, Ohizumi, Y, Tuerhong, M & Guo, Y 2016, 'Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects', Fitoterapia, vol. 113, pp. 151-157. https://doi.org/10.1016/j.fitote.2016.07.012
Xu, Jing ; Li, Shen ; Sun, Xiaocong ; Ma, Jun ; Liu, Feng ; Tong, Ling ; Lee, Dongho ; Ohizumi, Yasushi ; Tuerhong, Muhetaer ; Guo, Yuanqiang. / Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects. In: Fitoterapia. 2016 ; Vol. 113. pp. 151-157.
@article{f6bfa76d71734caa9b4569c459143028,
title = "Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects",
abstract = "A phytochemical investigation of the leaves of Callicarpa kwangtungensis led to the isolation of three new diterpenoids (1–3), callipenes A–C, and eleven known analogues (4–14). Their structures were established on the basis of extensive analysis of NMR spectroscopic data, X-ray diffraction data, and experimental and calculated electronic circular dichroism spectra. Compounds 1 and 2 are rare abietane diterpenoids possessing a peroxide bridge. All of the isolates were found to inhibit LPS-induced NO production in BV-2 cells.",
keywords = "Abietane diterpenoids, Callicarpa kwangtungensis, Diterpenoids, NO inhibitory effects, TDDFT ECD calculations",
author = "Jing Xu and Shen Li and Xiaocong Sun and Jun Ma and Feng Liu and Ling Tong and Dongho Lee and Yasushi Ohizumi and Muhetaer Tuerhong and Yuanqiang Guo",
year = "2016",
month = "9",
day = "1",
doi = "10.1016/j.fitote.2016.07.012",
language = "English",
volume = "113",
pages = "151--157",
journal = "Fitoterapia",
issn = "0367-326X",
publisher = "Elsevier",

}

TY - JOUR

T1 - Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects

AU - Xu, Jing

AU - Li, Shen

AU - Sun, Xiaocong

AU - Ma, Jun

AU - Liu, Feng

AU - Tong, Ling

AU - Lee, Dongho

AU - Ohizumi, Yasushi

AU - Tuerhong, Muhetaer

AU - Guo, Yuanqiang

PY - 2016/9/1

Y1 - 2016/9/1

N2 - A phytochemical investigation of the leaves of Callicarpa kwangtungensis led to the isolation of three new diterpenoids (1–3), callipenes A–C, and eleven known analogues (4–14). Their structures were established on the basis of extensive analysis of NMR spectroscopic data, X-ray diffraction data, and experimental and calculated electronic circular dichroism spectra. Compounds 1 and 2 are rare abietane diterpenoids possessing a peroxide bridge. All of the isolates were found to inhibit LPS-induced NO production in BV-2 cells.

AB - A phytochemical investigation of the leaves of Callicarpa kwangtungensis led to the isolation of three new diterpenoids (1–3), callipenes A–C, and eleven known analogues (4–14). Their structures were established on the basis of extensive analysis of NMR spectroscopic data, X-ray diffraction data, and experimental and calculated electronic circular dichroism spectra. Compounds 1 and 2 are rare abietane diterpenoids possessing a peroxide bridge. All of the isolates were found to inhibit LPS-induced NO production in BV-2 cells.

KW - Abietane diterpenoids

KW - Callicarpa kwangtungensis

KW - Diterpenoids

KW - NO inhibitory effects

KW - TDDFT ECD calculations

UR - http://www.scopus.com/inward/record.url?scp=84981240572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84981240572&partnerID=8YFLogxK

U2 - 10.1016/j.fitote.2016.07.012

DO - 10.1016/j.fitote.2016.07.012

M3 - Article

VL - 113

SP - 151

EP - 157

JO - Fitoterapia

JF - Fitoterapia

SN - 0367-326X

ER -