@article{0d17deb4ee654c84989fdf77f925da95,
title = "Diterpenoids from the leaves of Casearia kurzii showing cytotoxic activities",
abstract = "A phytochemical investigation to obtain bioactive substances as lead compounds or agents for cancer led to the obtainment of six new and two known clerodane diterpenoids from the leaves of Casearia kurzii. Their structures were elucidated using NMR techniques and electronic circular dichroism (ECD) calculations. The subsequent biological cytotoxicity evaluation of these isolates toward human lung cancer A549, human cervical cancer HeLa, human chronic myeloid leukemia K562, and human hepatocellular carcinoma HepG2 was carried out. The most active compound 4 with an IC50 value of 9.7 μM against HepG2 cells was selected to examine the cytotoxic mechanism, which induced the apoptosis and arrested the HepG2 cell cycle at S stage. The in vivo zebrafish experiments revealed that compound 4 had the property of inhibiting tumor proliferation and migration.",
keywords = "Apoptosis, Casearia kurzii, Cell cycle, Clerodane diterpenoids, Cytotoxic activities, Zebrafish xenograft model",
author = "Yue Liang and Qi Zhang and Xueyuan Yang and Ying Li and Xuke Zhang and Yuhao Li and Qing Du and Jin, {Da Qing} and Jianlin Cui and Namrita Lall and Muhetaer Tuerhong and Dongho Lee and Munira Abudukeremu and Jing Xu and Ling Shuai and Yuanqiang Guo",
note = "Funding Information: This research was financially supported by the National Key Research and Development Program of China (No. 2018YFA0507204), the National Natural Science Foundation of China (Nos. U1703107 and U1801288), Hundred Young Academic Leaders Program of Nankai University, the Natural Science Foundation of Tianjin (No. 19JCYBJC28100), State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2019-B01), and the open project of Key Laboratory of Xinjiang Uygur Autonomous Region (Nos. 2015KL030 and 2017D04019). Funding Information: This research was financially supported by the National Key Research and Development Program of China (No. 2018YFA0507204 ), the National Natural Science Foundation of China (Nos. U1703107 and U1801288 ), Hundred Young Academic Leaders Program of Nankai University , the Natural Science Foundation of Tianjin (No. 19JCYBJC28100 ), State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources ( Guangxi Normal University , No. CMEMR2019-B01 ), and the open project of Key Laboratory of Xinjiang Uygur Autonomous Region (Nos. 2015KL030 and 2017D04019 ). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = may,
doi = "10.1016/j.bioorg.2020.103741",
language = "English",
volume = "98",
journal = "Bioorganic Chemistry",
issn = "0045-2068",
publisher = "Academic Press Inc.",
}
