Diterpenoids from the Roots of Euphorbia fischeriana with Inhibitory Effects on Nitric Oxide Production

Jin Woo Lee, Chul Lee, Qinghao Jin, Hari Jang, Dongho Lee, Ha Jin Lee, Jong Won Shin, Sang Bae Han, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang

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21 Citations (Scopus)

Abstract

Bioactivity-guided isolation of a methanolic extract of Euphorbia fischeriana led to the isolation of four new abietane-type diterpenoids, fischeriolides A-D (1-4), together with 11 known diterpenoids. Their structures were elucidated based on the interpretation of 1D and 2D NMR spectroscopic and HRESIMS data. The absolute configuration of compound 3 was determined by single-crystal X-ray diffraction analysis and electronic circular dichroism methods. Compounds 5-9 exhibited inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages with IC50 values in the range 4.9-12.6 μM.

Original languageEnglish
Pages (from-to)126-131
Number of pages6
JournalJournal of Natural Products
Volume79
Issue number1
DOIs
Publication statusPublished - 2016 Jan 22

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ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Organic Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine

Cite this

Lee, J. W., Lee, C., Jin, Q., Jang, H., Lee, D., Lee, H. J., Shin, J. W., Han, S. B., Hong, J. T., Kim, Y., Lee, M. K., & Hwang, B. Y. (2016). Diterpenoids from the Roots of Euphorbia fischeriana with Inhibitory Effects on Nitric Oxide Production. Journal of Natural Products, 79(1), 126-131. https://doi.org/10.1021/acs.jnatprod.5b00789