Divalent metal ion-mediated assembly of spherical nucleic acids

the case study of Cu2+

Jang Ho Joo, Jae-Seung Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Despite the critical functions of divalent metal ions (M2+s) in association with duplex DNA, fundamental and general interactions of M2+s with spherical nucleic acids (SNAs) composed of single-stranded DNA have rarely been investigated. We have explored that the coordinative nature of the M2+-SNA binding mediates the temperature- and base composition-dependent reversible assemblies of SNAs even without the need of complementary counterparts for duplex-interconnection, additional monovalent metal ions for charge screening, or pre-designed sequences for any non-Watson-Crick base-pairing, all of which are essential for the conventional assembly of SNAs. Cu2+ has been identified to maximize the reversible assembly properties in relation to this M2+-mediated DNA bond, and has been further qualitatively and quantitatively investigated in detail as a model system.

Original languageEnglish
Pages (from-to)30292-30299
Number of pages8
JournalPhysical Chemistry Chemical Physics
Volume17
Issue number45
DOIs
Publication statusPublished - 2015 Oct 19

Fingerprint

nucleic acids
Nucleic Acids
Metal ions
metal ions
assembly
Metals
Ions
deoxyribonucleic acid
Single-Stranded DNA
DNA
Base Composition
Base Pairing
assemblies
Screening
screening
Association reactions
Temperature
Chemical analysis
interactions
temperature

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Physics and Astronomy(all)

Cite this

Divalent metal ion-mediated assembly of spherical nucleic acids : the case study of Cu2+. / Joo, Jang Ho; Lee, Jae-Seung.

In: Physical Chemistry Chemical Physics, Vol. 17, No. 45, 19.10.2015, p. 30292-30299.

Research output: Contribution to journalArticle

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