DNA repair capacity marks susceptibility in pediatric asthma patients following low levels of polycyclic aromatic hydrocarbon exposure

Yanghee Kim, Eun Il Lee, Yunjeong Kim, Young Yoo, Ji-Tae Choung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We studied DNA damage, DNA repair capacity and other oxidative stress markers with environmental polycyclic aromatic hydrocarbon (PAH) exposure to find susceptible groups to show significant correlation between PAH exposure and studied markers. The total of study subjects were fifty five children from 6 to 9 years old including thirty six control group and nineteen asthma patients. No significant correlation between DNA damage and exposure markers was found among control group and asthma patients based on total antioxidants activity and glutathione/oxidized glutathione (GSH/GSSG) ratio. However, significant correlation was found between Tail DNA and 2-naphthol in high residual DNA damage group (20 upper percentile group) (r=0. 63, p=0. 038) who showed low DNA repair capacity. These studies revealed that low DNA repair capacity in children may render this population susceptible to environmental exposure including DNA damage-causing agents.

Original languageEnglish
Pages (from-to)14-21
Number of pages8
JournalToxicology and Environmental Health Sciences
Volume3
Issue number1
DOIs
Publication statusPublished - 2011 Dec 1

Fingerprint

Pediatrics
Polycyclic Aromatic Hydrocarbons
DNA Repair
DNA Damage
Repair
Asthma
Glutathione Disulfide
DNA
Control Groups
Environmental Exposure
Glutathione
Oxidative Stress
Antioxidants
Oxidative stress
Population

Keywords

  • DNA damage
  • DNA repair capacity
  • Environmental air pollutant

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

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