Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy

Keun Sang Oh, Kyungim Kim, Byeong Deok Yoon, Hye Jin Lee, Dal Yong Park, Eun Yeong Kim, Kiho Lee, Jae Hong Seo, Soon Hong Yuk

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A mixture of docetaxel (DTX) and Solutol® HS 15 (Solutol) transiently formed nanodroplets when it was suspended in an aqueous medium. However, nanodroplets that comprised DTX and Solutol showed a rapid precipitation of DTX because of their unstable characteristics in the aqueous medium. The incorporation of nanodroplets that comprised DTX and Solutol through vesicle fusion and subsequent stabilization was designed to prepare multilayer nanoparticles (NPs) with a DTX-loaded Solutol nanodroplet (as template NPs) core for an efficient delivery of DTX as a chemotherapeutic drug. As a result, the DTX-loaded Solutol nanodroplets (~11.7 nm) were observed to have an increased average diameter (from 11.7 nm to 156.1 nm) and a good stability of the hydrated NPs without precipitation of DTX by vesicle fusion and multilayered structure, respectively. Also, a long circulation of the multilayer NPs was observed, and this was due to the presence of Pluronic F-68 on the surface of the multilayer NPs. This led to an improved antitumor efficacy based on the enhanced permeation and retention effect. Therefore, this study indicated that the multilayer NPs have a considerable potential as a drug delivery system with an enhanced therapeutic efficacy by blood circulation and with low side effects.

Original languageEnglish
Pages (from-to)1077-1087
Number of pages11
JournalInternational Journal of Nanomedicine
Volume11
DOIs
Publication statusPublished - 2016 Mar 16

Fingerprint

docetaxel
Nanoparticles
Multilayers
Neoplasms
Fusion reactions
Therapeutics
Hemodynamics
Poloxamer
Permeation
Blood Circulation
Drug Delivery Systems
Stabilization

Keywords

  • Cancer therapy
  • Docetaxel
  • Multilayer nanoparticles
  • Pluronic F-68
  • Solutol

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Organic Chemistry
  • Drug Discovery

Cite this

Oh, K. S., Kim, K., Yoon, B. D., Lee, H. J., Park, D. Y., Kim, E. Y., ... Yuk, S. H. (2016). Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy. International Journal of Nanomedicine, 11, 1077-1087. https://doi.org/10.2147/IJN.S100170

Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy. / Oh, Keun Sang; Kim, Kyungim; Yoon, Byeong Deok; Lee, Hye Jin; Park, Dal Yong; Kim, Eun Yeong; Lee, Kiho; Seo, Jae Hong; Yuk, Soon Hong.

In: International Journal of Nanomedicine, Vol. 11, 16.03.2016, p. 1077-1087.

Research output: Contribution to journalArticle

Oh, KS, Kim, K, Yoon, BD, Lee, HJ, Park, DY, Kim, EY, Lee, K, Seo, JH & Yuk, SH 2016, 'Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy', International Journal of Nanomedicine, vol. 11, pp. 1077-1087. https://doi.org/10.2147/IJN.S100170
Oh, Keun Sang ; Kim, Kyungim ; Yoon, Byeong Deok ; Lee, Hye Jin ; Park, Dal Yong ; Kim, Eun Yeong ; Lee, Kiho ; Seo, Jae Hong ; Yuk, Soon Hong. / Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy. In: International Journal of Nanomedicine. 2016 ; Vol. 11. pp. 1077-1087.
@article{e39cf7bab25b40cbaaa51a332081943a,
title = "Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy",
abstract = "A mixture of docetaxel (DTX) and Solutol{\circledR} HS 15 (Solutol) transiently formed nanodroplets when it was suspended in an aqueous medium. However, nanodroplets that comprised DTX and Solutol showed a rapid precipitation of DTX because of their unstable characteristics in the aqueous medium. The incorporation of nanodroplets that comprised DTX and Solutol through vesicle fusion and subsequent stabilization was designed to prepare multilayer nanoparticles (NPs) with a DTX-loaded Solutol nanodroplet (as template NPs) core for an efficient delivery of DTX as a chemotherapeutic drug. As a result, the DTX-loaded Solutol nanodroplets (~11.7 nm) were observed to have an increased average diameter (from 11.7 nm to 156.1 nm) and a good stability of the hydrated NPs without precipitation of DTX by vesicle fusion and multilayered structure, respectively. Also, a long circulation of the multilayer NPs was observed, and this was due to the presence of Pluronic F-68 on the surface of the multilayer NPs. This led to an improved antitumor efficacy based on the enhanced permeation and retention effect. Therefore, this study indicated that the multilayer NPs have a considerable potential as a drug delivery system with an enhanced therapeutic efficacy by blood circulation and with low side effects.",
keywords = "Cancer therapy, Docetaxel, Multilayer nanoparticles, Pluronic F-68, Solutol",
author = "Oh, {Keun Sang} and Kyungim Kim and Yoon, {Byeong Deok} and Lee, {Hye Jin} and Park, {Dal Yong} and Kim, {Eun Yeong} and Kiho Lee and Seo, {Jae Hong} and Yuk, {Soon Hong}",
year = "2016",
month = "3",
day = "16",
doi = "10.2147/IJN.S100170",
language = "English",
volume = "11",
pages = "1077--1087",
journal = "International Journal of Nanomedicine",
issn = "1176-9114",
publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy

AU - Oh, Keun Sang

AU - Kim, Kyungim

AU - Yoon, Byeong Deok

AU - Lee, Hye Jin

AU - Park, Dal Yong

AU - Kim, Eun Yeong

AU - Lee, Kiho

AU - Seo, Jae Hong

AU - Yuk, Soon Hong

PY - 2016/3/16

Y1 - 2016/3/16

N2 - A mixture of docetaxel (DTX) and Solutol® HS 15 (Solutol) transiently formed nanodroplets when it was suspended in an aqueous medium. However, nanodroplets that comprised DTX and Solutol showed a rapid precipitation of DTX because of their unstable characteristics in the aqueous medium. The incorporation of nanodroplets that comprised DTX and Solutol through vesicle fusion and subsequent stabilization was designed to prepare multilayer nanoparticles (NPs) with a DTX-loaded Solutol nanodroplet (as template NPs) core for an efficient delivery of DTX as a chemotherapeutic drug. As a result, the DTX-loaded Solutol nanodroplets (~11.7 nm) were observed to have an increased average diameter (from 11.7 nm to 156.1 nm) and a good stability of the hydrated NPs without precipitation of DTX by vesicle fusion and multilayered structure, respectively. Also, a long circulation of the multilayer NPs was observed, and this was due to the presence of Pluronic F-68 on the surface of the multilayer NPs. This led to an improved antitumor efficacy based on the enhanced permeation and retention effect. Therefore, this study indicated that the multilayer NPs have a considerable potential as a drug delivery system with an enhanced therapeutic efficacy by blood circulation and with low side effects.

AB - A mixture of docetaxel (DTX) and Solutol® HS 15 (Solutol) transiently formed nanodroplets when it was suspended in an aqueous medium. However, nanodroplets that comprised DTX and Solutol showed a rapid precipitation of DTX because of their unstable characteristics in the aqueous medium. The incorporation of nanodroplets that comprised DTX and Solutol through vesicle fusion and subsequent stabilization was designed to prepare multilayer nanoparticles (NPs) with a DTX-loaded Solutol nanodroplet (as template NPs) core for an efficient delivery of DTX as a chemotherapeutic drug. As a result, the DTX-loaded Solutol nanodroplets (~11.7 nm) were observed to have an increased average diameter (from 11.7 nm to 156.1 nm) and a good stability of the hydrated NPs without precipitation of DTX by vesicle fusion and multilayered structure, respectively. Also, a long circulation of the multilayer NPs was observed, and this was due to the presence of Pluronic F-68 on the surface of the multilayer NPs. This led to an improved antitumor efficacy based on the enhanced permeation and retention effect. Therefore, this study indicated that the multilayer NPs have a considerable potential as a drug delivery system with an enhanced therapeutic efficacy by blood circulation and with low side effects.

KW - Cancer therapy

KW - Docetaxel

KW - Multilayer nanoparticles

KW - Pluronic F-68

KW - Solutol

UR - http://www.scopus.com/inward/record.url?scp=84961239727&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961239727&partnerID=8YFLogxK

U2 - 10.2147/IJN.S100170

DO - 10.2147/IJN.S100170

M3 - Article

C2 - 27042062

AN - SCOPUS:84961239727

VL - 11

SP - 1077

EP - 1087

JO - International Journal of Nanomedicine

JF - International Journal of Nanomedicine

SN - 1176-9114

ER -