Abstract
Purpose: The purpose of this study was to evaluate the effects of age at onset of the first major depressive episode on the clinical features of individuals with major depressive disorder (MDD) in a large cohort of Korean depressed patients.
Materials and Methods: We recruited 419 MDD patients of age over 18 years from the Clinical Research Center for Depression study in South Korea. At the start of the study, the onset age of the first major depressive episode was self-reported by the subjects. The subjects were divided into four age-at-onset subgroups: childhood and adolescent onset (ages <18), early adult onset (ages 18–44), middle adult onset (ages 45–59), and late onset (ages 60+). Using analysis of covariance (ANCOVA) and ordinal logistic regression analysis with adjusting the effect of age, the relationships between clinical features and age at onset of MDD were evaluated.
Results: There was an apparent, but inconsistent correlation between clinical features and age at onset. Earlier onset MDD was significantly associated with higher proportion of female gender [adjusted odds ratio (AOR)=0.570, p=0.022], more previous suicide attempts (AOR=0.635, p=0.038), greater number of previous depressive episodes (F=3.475, p=0.016) and higher scores on the brief psychiatric rating scale (F=3.254, p=0.022), its negative symptom subscale (F=6.082, p<0.0001), and the alcohol use disorder identification test (F=7.061, p<0.0001).
Conclusion: Early age at onset may increase the likelihood of distinguishable MDD subtype, and age at onset of the first major depressive episode is a promising clinical indicator for the clinical presentation, course, and outcome of MDD.
| Original language | English |
|---|---|
| Pages (from-to) | 1712-1720 |
| Number of pages | 9 |
| Journal | Yonsei Medical Journal |
| Volume | 55 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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Keywords
- Age at onset
- Clinical indicator
- Major depressive disorder
- Subtype
ASJC Scopus subject areas
- Medicine(all)
Cite this
Does age at onset of first major depressive episode indicate the subtype of major depressive disorder? The clinical research center for depression study. / Park, Seon Cheol; Hahn, Sang Woo; Hwang, Tae Yeon; Kim, Jae Min; Jun, Tae Youn; Lee, Min-Soo; Kim, Jung Bum; Yim, Hyeon Woo; Park, Yong Chon.
In: Yonsei Medical Journal, Vol. 55, No. 6, 01.01.2014, p. 1712-1720.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Does age at onset of first major depressive episode indicate the subtype of major depressive disorder?
T2 - The clinical research center for depression study
AU - Park, Seon Cheol
AU - Hahn, Sang Woo
AU - Hwang, Tae Yeon
AU - Kim, Jae Min
AU - Jun, Tae Youn
AU - Lee, Min-Soo
AU - Kim, Jung Bum
AU - Yim, Hyeon Woo
AU - Park, Yong Chon
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Purpose: The purpose of this study was to evaluate the effects of age at onset of the first major depressive episode on the clinical features of individuals with major depressive disorder (MDD) in a large cohort of Korean depressed patients.Materials and Methods: We recruited 419 MDD patients of age over 18 years from the Clinical Research Center for Depression study in South Korea. At the start of the study, the onset age of the first major depressive episode was self-reported by the subjects. The subjects were divided into four age-at-onset subgroups: childhood and adolescent onset (ages <18), early adult onset (ages 18–44), middle adult onset (ages 45–59), and late onset (ages 60+). Using analysis of covariance (ANCOVA) and ordinal logistic regression analysis with adjusting the effect of age, the relationships between clinical features and age at onset of MDD were evaluated.Results: There was an apparent, but inconsistent correlation between clinical features and age at onset. Earlier onset MDD was significantly associated with higher proportion of female gender [adjusted odds ratio (AOR)=0.570, p=0.022], more previous suicide attempts (AOR=0.635, p=0.038), greater number of previous depressive episodes (F=3.475, p=0.016) and higher scores on the brief psychiatric rating scale (F=3.254, p=0.022), its negative symptom subscale (F=6.082, p<0.0001), and the alcohol use disorder identification test (F=7.061, p<0.0001).Conclusion: Early age at onset may increase the likelihood of distinguishable MDD subtype, and age at onset of the first major depressive episode is a promising clinical indicator for the clinical presentation, course, and outcome of MDD.
AB - Purpose: The purpose of this study was to evaluate the effects of age at onset of the first major depressive episode on the clinical features of individuals with major depressive disorder (MDD) in a large cohort of Korean depressed patients.Materials and Methods: We recruited 419 MDD patients of age over 18 years from the Clinical Research Center for Depression study in South Korea. At the start of the study, the onset age of the first major depressive episode was self-reported by the subjects. The subjects were divided into four age-at-onset subgroups: childhood and adolescent onset (ages <18), early adult onset (ages 18–44), middle adult onset (ages 45–59), and late onset (ages 60+). Using analysis of covariance (ANCOVA) and ordinal logistic regression analysis with adjusting the effect of age, the relationships between clinical features and age at onset of MDD were evaluated.Results: There was an apparent, but inconsistent correlation between clinical features and age at onset. Earlier onset MDD was significantly associated with higher proportion of female gender [adjusted odds ratio (AOR)=0.570, p=0.022], more previous suicide attempts (AOR=0.635, p=0.038), greater number of previous depressive episodes (F=3.475, p=0.016) and higher scores on the brief psychiatric rating scale (F=3.254, p=0.022), its negative symptom subscale (F=6.082, p<0.0001), and the alcohol use disorder identification test (F=7.061, p<0.0001).Conclusion: Early age at onset may increase the likelihood of distinguishable MDD subtype, and age at onset of the first major depressive episode is a promising clinical indicator for the clinical presentation, course, and outcome of MDD.
KW - Age at onset
KW - Clinical indicator
KW - Major depressive disorder
KW - Subtype
UR - http://www.scopus.com/inward/record.url?scp=84908257617&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908257617&partnerID=8YFLogxK
U2 - 10.3349/ymj.2014.55.6.1712
DO - 10.3349/ymj.2014.55.6.1712
M3 - Article
C2 - 25323911
AN - SCOPUS:84908257617
VL - 55
SP - 1712
EP - 1720
JO - Yonsei Medical Journal
JF - Yonsei Medical Journal
SN - 0513-5796
IS - 6
ER -