Does immediate breast reconstruction after mastectomy affect the initiation of adjuvant chemotherapy?

Jeonghui Lee, Se Kyung Lee, Sangmin Kim, Min Young Koo, Min Young Choi, Soo Youn Bae, Dong Hui Cho, Jiyoung Kim, Seung Pil Jung, Jun Ho Choe, Jung Han Kim, Jee Soo Kim, Jeong Eon Lee, Jung Hyun Yang, Seok Jin Nam

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: The frequency of immediate breast reconstruction (IBR) is increasing, and the types of reconstruction used are diverse. Adjuvant chemotherapy is a life-saving intervention in selected high-risk breast cancer patients. The aim of our study was to determine how IBR and type of reconstruction affect the timing of the initiation of chemotherapy. Methods: We obtained data from female breast cancer patients treated by mastectomy with IBR (IBR group) and without IBR (mastectomy only group) who received adjuvant chemotherapy between January 1, 2008, and December 31, 2010. We retrospectively collected data including patient characteristics, disease characteristics, treatment details, and treatment outcomes from our institutional electronic patient database and medical treatment records. The reconstruction types were categorized as deep inferior epigastric perforator (DIEP) fap, latissimus dorsi (LD) fap and tissue expander/implant (TEI). Results: In total, 595 patients were included in this study. Of these patients, 43 underwent mastectomy with IBR (IBR group) and 552 patients did not undergo reconstruction (mastectomy only group). There was significant difference in the timing of the initiation of chemotherapy between the two groups (p< 0.0001). There were no cases of delays of more than 12 weeks. In the IBR group, 20 patients received TEI, 9 patients were treated by the insertion DIEP faps, and 14 patients were treated by LD faps. There were no significant differences in the timing of chemotherapy according to the type of reconstruction (p= 0.095). Conclusion: IBR delays the initiation of chemotherapy, but does not lead to omission or significant clinical delay in chemotherapy. Further, the type of reconstruction does not affect the timing of chemotherapy.

Original languageEnglish
Pages (from-to)322-327
Number of pages6
JournalJournal of Breast Cancer
Volume14
Issue number4
DOIs
Publication statusPublished - 2011 Dec 1
Externally publishedYes

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Mammaplasty
Mastectomy
Adjuvant Chemotherapy
Drug Therapy
Tissue Expansion Devices
Superficial Back Muscles
Breast Neoplasms
Medical Records
Databases

Keywords

  • Adjuvant chemotherapy
  • Breast neoplasms
  • Breast reconstruction

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Does immediate breast reconstruction after mastectomy affect the initiation of adjuvant chemotherapy? / Lee, Jeonghui; Lee, Se Kyung; Kim, Sangmin; Koo, Min Young; Choi, Min Young; Bae, Soo Youn; Cho, Dong Hui; Kim, Jiyoung; Jung, Seung Pil; Choe, Jun Ho; Kim, Jung Han; Kim, Jee Soo; Lee, Jeong Eon; Yang, Jung Hyun; Nam, Seok Jin.

In: Journal of Breast Cancer, Vol. 14, No. 4, 01.12.2011, p. 322-327.

Research output: Contribution to journalArticle

Lee, J, Lee, SK, Kim, S, Koo, MY, Choi, MY, Bae, SY, Cho, DH, Kim, J, Jung, SP, Choe, JH, Kim, JH, Kim, JS, Lee, JE, Yang, JH & Nam, SJ 2011, 'Does immediate breast reconstruction after mastectomy affect the initiation of adjuvant chemotherapy?', Journal of Breast Cancer, vol. 14, no. 4, pp. 322-327. https://doi.org/10.4048/jbc.2011.14.4.322
Lee, Jeonghui ; Lee, Se Kyung ; Kim, Sangmin ; Koo, Min Young ; Choi, Min Young ; Bae, Soo Youn ; Cho, Dong Hui ; Kim, Jiyoung ; Jung, Seung Pil ; Choe, Jun Ho ; Kim, Jung Han ; Kim, Jee Soo ; Lee, Jeong Eon ; Yang, Jung Hyun ; Nam, Seok Jin. / Does immediate breast reconstruction after mastectomy affect the initiation of adjuvant chemotherapy?. In: Journal of Breast Cancer. 2011 ; Vol. 14, No. 4. pp. 322-327.
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abstract = "Purpose: The frequency of immediate breast reconstruction (IBR) is increasing, and the types of reconstruction used are diverse. Adjuvant chemotherapy is a life-saving intervention in selected high-risk breast cancer patients. The aim of our study was to determine how IBR and type of reconstruction affect the timing of the initiation of chemotherapy. Methods: We obtained data from female breast cancer patients treated by mastectomy with IBR (IBR group) and without IBR (mastectomy only group) who received adjuvant chemotherapy between January 1, 2008, and December 31, 2010. We retrospectively collected data including patient characteristics, disease characteristics, treatment details, and treatment outcomes from our institutional electronic patient database and medical treatment records. The reconstruction types were categorized as deep inferior epigastric perforator (DIEP) fap, latissimus dorsi (LD) fap and tissue expander/implant (TEI). Results: In total, 595 patients were included in this study. Of these patients, 43 underwent mastectomy with IBR (IBR group) and 552 patients did not undergo reconstruction (mastectomy only group). There was significant difference in the timing of the initiation of chemotherapy between the two groups (p< 0.0001). There were no cases of delays of more than 12 weeks. In the IBR group, 20 patients received TEI, 9 patients were treated by the insertion DIEP faps, and 14 patients were treated by LD faps. There were no significant differences in the timing of chemotherapy according to the type of reconstruction (p= 0.095). Conclusion: IBR delays the initiation of chemotherapy, but does not lead to omission or significant clinical delay in chemotherapy. Further, the type of reconstruction does not affect the timing of chemotherapy.",
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AU - Lee, Jeonghui

AU - Lee, Se Kyung

AU - Kim, Sangmin

AU - Koo, Min Young

AU - Choi, Min Young

AU - Bae, Soo Youn

AU - Cho, Dong Hui

AU - Kim, Jiyoung

AU - Jung, Seung Pil

AU - Choe, Jun Ho

AU - Kim, Jung Han

AU - Kim, Jee Soo

AU - Lee, Jeong Eon

AU - Yang, Jung Hyun

AU - Nam, Seok Jin

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N2 - Purpose: The frequency of immediate breast reconstruction (IBR) is increasing, and the types of reconstruction used are diverse. Adjuvant chemotherapy is a life-saving intervention in selected high-risk breast cancer patients. The aim of our study was to determine how IBR and type of reconstruction affect the timing of the initiation of chemotherapy. Methods: We obtained data from female breast cancer patients treated by mastectomy with IBR (IBR group) and without IBR (mastectomy only group) who received adjuvant chemotherapy between January 1, 2008, and December 31, 2010. We retrospectively collected data including patient characteristics, disease characteristics, treatment details, and treatment outcomes from our institutional electronic patient database and medical treatment records. The reconstruction types were categorized as deep inferior epigastric perforator (DIEP) fap, latissimus dorsi (LD) fap and tissue expander/implant (TEI). Results: In total, 595 patients were included in this study. Of these patients, 43 underwent mastectomy with IBR (IBR group) and 552 patients did not undergo reconstruction (mastectomy only group). There was significant difference in the timing of the initiation of chemotherapy between the two groups (p< 0.0001). There were no cases of delays of more than 12 weeks. In the IBR group, 20 patients received TEI, 9 patients were treated by the insertion DIEP faps, and 14 patients were treated by LD faps. There were no significant differences in the timing of chemotherapy according to the type of reconstruction (p= 0.095). Conclusion: IBR delays the initiation of chemotherapy, but does not lead to omission or significant clinical delay in chemotherapy. Further, the type of reconstruction does not affect the timing of chemotherapy.

AB - Purpose: The frequency of immediate breast reconstruction (IBR) is increasing, and the types of reconstruction used are diverse. Adjuvant chemotherapy is a life-saving intervention in selected high-risk breast cancer patients. The aim of our study was to determine how IBR and type of reconstruction affect the timing of the initiation of chemotherapy. Methods: We obtained data from female breast cancer patients treated by mastectomy with IBR (IBR group) and without IBR (mastectomy only group) who received adjuvant chemotherapy between January 1, 2008, and December 31, 2010. We retrospectively collected data including patient characteristics, disease characteristics, treatment details, and treatment outcomes from our institutional electronic patient database and medical treatment records. The reconstruction types were categorized as deep inferior epigastric perforator (DIEP) fap, latissimus dorsi (LD) fap and tissue expander/implant (TEI). Results: In total, 595 patients were included in this study. Of these patients, 43 underwent mastectomy with IBR (IBR group) and 552 patients did not undergo reconstruction (mastectomy only group). There was significant difference in the timing of the initiation of chemotherapy between the two groups (p< 0.0001). There were no cases of delays of more than 12 weeks. In the IBR group, 20 patients received TEI, 9 patients were treated by the insertion DIEP faps, and 14 patients were treated by LD faps. There were no significant differences in the timing of chemotherapy according to the type of reconstruction (p= 0.095). Conclusion: IBR delays the initiation of chemotherapy, but does not lead to omission or significant clinical delay in chemotherapy. Further, the type of reconstruction does not affect the timing of chemotherapy.

KW - Adjuvant chemotherapy

KW - Breast neoplasms

KW - Breast reconstruction

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