Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior

Bokyeong Kim, Sehyoun Yoon, Ryuichi Nakajima, Hyo Jin Lee, Hee Jeong Lim, Yeon Kyung Lee, June Seek Choi, Bongjune Yoon, George J. Augustine, Ja-Hyun Baik

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Impulsivity is closely associated with addictive disorders, and changes in the brain dopamine system have been proposed to affect impulse control in reward-related behaviors. However, the central neural pathways through which the dopamine system controls impulsive behavior are still unclear. We found that the absence of the D2 dopamine receptor (D2R) increased impulsive behavior in mice, whereas restoration of D2R expression specifically in the central amygdala (CeA) of D2R knockout mice (Drd2-/-) normalized their enhanced impulsivity. Inhibitory synaptic output from D2R-expressing neurons in the CeA underlies modulation of impulsive behavior because optogenetic activation of D2R-positive inhibitory neurons that project from the CeA to the bed nucleus of the stria terminalis (BNST) attenuate such behavior. Our identification of the key contribution of D2R-expressing neurons in the CeA → BNST circuit to the control of impulsive behavior reveals a pathway that could serve as a target for approaches to the management of neuropsychiatric disorders associated with impulsivity.

Original languageEnglish
Pages (from-to)E10730-E10739
JournalProceedings of the National Academy of Sciences of the United States of America
Volume115
Issue number45
DOIs
Publication statusPublished - 2018 Nov 6

Fingerprint

Septal Nuclei
Dopamine D2 Receptors
Impulsive Behavior
Neurons
Dopamine
Optogenetics
Neural Pathways
Central Amygdaloid Nucleus
Reward
Knockout Mice
Brain

Keywords

  • Central amygdala
  • Dopamine receptor
  • Impulsivity
  • Neural circuit
  • Optogenetics

ASJC Scopus subject areas

  • General

Cite this

Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior. / Kim, Bokyeong; Yoon, Sehyoun; Nakajima, Ryuichi; Lee, Hyo Jin; Lim, Hee Jeong; Lee, Yeon Kyung; Choi, June Seek; Yoon, Bongjune; Augustine, George J.; Baik, Ja-Hyun.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 45, 06.11.2018, p. E10730-E10739.

Research output: Contribution to journalArticle

Kim, Bokyeong ; Yoon, Sehyoun ; Nakajima, Ryuichi ; Lee, Hyo Jin ; Lim, Hee Jeong ; Lee, Yeon Kyung ; Choi, June Seek ; Yoon, Bongjune ; Augustine, George J. ; Baik, Ja-Hyun. / Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior. In: Proceedings of the National Academy of Sciences of the United States of America. 2018 ; Vol. 115, No. 45. pp. E10730-E10739.
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