Dopamine D2 receptor-mediated epidermal growth factor receptor transactivation through a disintegrin and metalloprotease regulates dopaminergic neuron development via extracellular signal-related kinase activation

Sehyoun Yoon, Ja Hyun Baik

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background:Dopamine D2R-mediated ERK activation regulates dopaminergic neuronal development. Results:D2R activation induces shedding of heparin-binding EGF by activating a disintegrin and metalloproteinase (ADAM) 10 or 17, causing EGFR transactivation in mesencephalic neurons. Conclusion:D2R-mediated ERK activation regulates mesencephalic dopaminergic neuron development via EGFR transactivation through ADAM10/17. Significance:Dopaminergic system alteration through D2R-ADAM-EGFR signaling maybe associated with dopamine-related neurological/psychiatric disorders.

Original languageEnglish
Pages (from-to)28435-28446
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
Publication statusPublished - 2013 Oct 4

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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