Dopamine D2 receptors in signal transduction and behavior

Roberto Picetti, Adolfo Saiardi, Tarek Abdel Samad, Yuri Bozzi, Ja-Hyun Baik, Emiliana Borrelli

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

The dopamine D2 receptor belongs to the family of seven transmembrane domain G-protein-coupled receptors and is highly expressed in the central nervous system and the pituitary gland. The binding of dopamine to the D2 receptor is crucial for the regulation of diverse physiological functions, such as the control of locomotor activity and the synthesis of peptide hormones. Two alternatively spliced transcripts are generated from the D2 receptor gene and code for the D2L and D2S isoforms, which are 444 and 415 amino acids in length, respectively. These isoforms exhibit similar pharmacological characteristics and are expressed in the same cell types, with a ratio that normally favors expression of the longer isoform. The D2L isoform differs from D2S by the insertion of 29 amino acids in the putative third intracellular loop of the receptor. This loop is involved in the coupling of the receptor to different G proteins. Experiments have shown that the D2 isoforms have different G-protein-coupling affinities, suggesting that these receptors might serve different functions in vivo. Additionally, this difference in coupling affinity could be a mechanism to amplify the signal transduced by the binding of dopamine to D2 receptors. Important insights into D2 receptor function in vivo have been obtained by knocking out the D2 gene in mice. The Parkinsonian-like phenotype of D2-null mice demonstrates the importance of the D2 receptor for locomotor function.

Original languageEnglish
Pages (from-to)121-142
Number of pages22
JournalCritical Reviews in Neurobiology
Volume11
Issue number2-3
Publication statusPublished - 1997 Nov 3
Externally publishedYes

Fingerprint

Dopamine D2 Receptors
Signal Transduction
Protein Isoforms
GTP-Binding Proteins
Amino Acids
Peptide Hormones
Pituitary Gland
Locomotion
Genes
Central Nervous System
Pharmacology
Phenotype

Keywords

  • Basal ganglia
  • Knockout
  • Parkinson's disease
  • Pharmacology
  • Seven transmembrane domain G-protein-coupled receptors
  • Signal transduction

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology
  • Neuroscience(all)

Cite this

Picetti, R., Saiardi, A., Samad, T. A., Bozzi, Y., Baik, J-H., & Borrelli, E. (1997). Dopamine D2 receptors in signal transduction and behavior. Critical Reviews in Neurobiology, 11(2-3), 121-142.

Dopamine D2 receptors in signal transduction and behavior. / Picetti, Roberto; Saiardi, Adolfo; Samad, Tarek Abdel; Bozzi, Yuri; Baik, Ja-Hyun; Borrelli, Emiliana.

In: Critical Reviews in Neurobiology, Vol. 11, No. 2-3, 03.11.1997, p. 121-142.

Research output: Contribution to journalArticle

Picetti, R, Saiardi, A, Samad, TA, Bozzi, Y, Baik, J-H & Borrelli, E 1997, 'Dopamine D2 receptors in signal transduction and behavior', Critical Reviews in Neurobiology, vol. 11, no. 2-3, pp. 121-142.
Picetti R, Saiardi A, Samad TA, Bozzi Y, Baik J-H, Borrelli E. Dopamine D2 receptors in signal transduction and behavior. Critical Reviews in Neurobiology. 1997 Nov 3;11(2-3):121-142.
Picetti, Roberto ; Saiardi, Adolfo ; Samad, Tarek Abdel ; Bozzi, Yuri ; Baik, Ja-Hyun ; Borrelli, Emiliana. / Dopamine D2 receptors in signal transduction and behavior. In: Critical Reviews in Neurobiology. 1997 ; Vol. 11, No. 2-3. pp. 121-142.
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