Abstract
Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic dopaminergic pathway. Changes in DA mesolimbic neurotransmission have been found to modify behavioral responses to various environmental stimuli associated with reward behaviors. Psychostimulants, drugs of abuse, and natural reward such as food can cause substantial synaptic modifications to the mesolimbic DA system. Recent studies using optogenetics and DREADDs, together with neuron-specific or circuit-specific genetic manipulations have improved our understanding of DA signaling in the reward circuit, and provided a means to identify the neural substrates of complex behaviors such as drug addiction and eating disorders. This review focuses on the role of the DA system in drug addiction and food motivation, with an overview of the role of D1 and D2 receptors in the control of reward-associated behaviors.
| Original language | English |
|---|---|
| Article number | 152 |
| Journal | Frontiers in Neural Circuits |
| Volume | 7 |
| Issue number | OCT |
| Publication status | Published - 2013 Oct 11 |
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Keywords
- Dopamine
- Dopamine receptor
- Drug addiction
- Food reward
- Reward circuit
ASJC Scopus subject areas
- Neuroscience (miscellaneous)
- Cellular and Molecular Neuroscience
- Sensory Systems
- Cognitive Neuroscience
Cite this
Dopamine signaling in reward-related behaviors. / Baik, Ja-Hyun.
In: Frontiers in Neural Circuits, Vol. 7, No. OCT, 152, 11.10.2013.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Dopamine signaling in reward-related behaviors
AU - Baik, Ja-Hyun
PY - 2013/10/11
Y1 - 2013/10/11
N2 - Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic dopaminergic pathway. Changes in DA mesolimbic neurotransmission have been found to modify behavioral responses to various environmental stimuli associated with reward behaviors. Psychostimulants, drugs of abuse, and natural reward such as food can cause substantial synaptic modifications to the mesolimbic DA system. Recent studies using optogenetics and DREADDs, together with neuron-specific or circuit-specific genetic manipulations have improved our understanding of DA signaling in the reward circuit, and provided a means to identify the neural substrates of complex behaviors such as drug addiction and eating disorders. This review focuses on the role of the DA system in drug addiction and food motivation, with an overview of the role of D1 and D2 receptors in the control of reward-associated behaviors.
AB - Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic dopaminergic pathway. Changes in DA mesolimbic neurotransmission have been found to modify behavioral responses to various environmental stimuli associated with reward behaviors. Psychostimulants, drugs of abuse, and natural reward such as food can cause substantial synaptic modifications to the mesolimbic DA system. Recent studies using optogenetics and DREADDs, together with neuron-specific or circuit-specific genetic manipulations have improved our understanding of DA signaling in the reward circuit, and provided a means to identify the neural substrates of complex behaviors such as drug addiction and eating disorders. This review focuses on the role of the DA system in drug addiction and food motivation, with an overview of the role of D1 and D2 receptors in the control of reward-associated behaviors.
KW - Dopamine
KW - Dopamine receptor
KW - Drug addiction
KW - Food reward
KW - Reward circuit
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M3 - Article
VL - 7
JO - Frontiers in Neural Circuits
JF - Frontiers in Neural Circuits
SN - 1662-5110
IS - OCT
M1 - 152
ER -