Dopamine signalling in mushroom bodies regulates temperature-preference behaviour in Drosophila

Sunhoe Bang, Seogang Hyun, Sung Tae Hong, Jongkyun Kang, Kyunghwa Jeong, Joong Jean Park, Joonho Choe, Jongkyeong Chung

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The ability to respond to environmental temperature variation is essential for survival in animals. Flies show robust temperature-preference behaviour (TPB) to find optimal temperatures. Recently, we have shown that Drosophila mushroom body (MB) functions as a center controlling TPB. However, neuromodulators that control the TPB in MB remain unknown. To identify the functions of dopamine in TPB, we have conducted various genetic studies in Drosophila. Inhibition of dopamine biosynthesis by genetic mutations or treatment with chemical inhibitors caused flies to prefer temperatures colder than normal. We also found that dopaminergic neurons are involved in TPB regulation, as the targeted inactivation of dopaminergic neurons by expression of a potassium channel (Kir2.1) induced flies with the loss of cold avoidance. Consistently, the mutant flies for dopamine receptor gene (DopR) also showed a cold temperature preference, which was rescued by MB-specific expression of DopR. Based on these results, we concluded that dopamine in MB is a key component in the homeostatic temperature control of Drosophila. The current findings will provide important bases to understand the logic of thermosensation and temperature preference decision in Drosophila.

Original languageEnglish
Article numbere1001346
JournalPLoS Genetics
Volume7
Issue number3
DOIs
Publication statusPublished - 2011 Mar

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cancer Research

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    Bang, S., Hyun, S., Hong, S. T., Kang, J., Jeong, K., Park, J. J., Choe, J., & Chung, J. (2011). Dopamine signalling in mushroom bodies regulates temperature-preference behaviour in Drosophila. PLoS Genetics, 7(3), [e1001346]. https://doi.org/10.1371/journal.pgen.1001346