Dose sparing strategy with intradermal influenza vaccination in patients with solid cancer

Yu Mi Jo, Joon Young Song, In Sook Hwang, Jacob Lee, Sang Cheul Oh, Jun Suk Kim, Sung Ran Kim, Woo Joo Kim, Hee Jin Cheong

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21 Citations (Scopus)

Abstract

Influenza vaccine is considered to reduce influenza- related morbidity and mortality in patients with underlying chronic medical conditions. Because of fear of vaccine shortage during an influenza pandemic, several antigen sparing strategies have been investigated. The immuno- genicity of intradermal influenza vaccination with one half the antigenic contents was compared to that of conventional intramuscular vaccination in patients with solid cancer, and adverse events were assessed after vaccination. There was no significant difference between the injection routes in the hemagglutinin inhibition (H)response and increase in the titer of A/H1N1, A/H3N2, and B 4-6 weeks after the vaccination; seroconversion factors increased by more than 2.5-fold. Seroresponse rates were more than 40% and seroprotection rates were above 70% against all three influenza strains irrespective of the vaccination routes. No serious events were observed and local skin reactions were more frequent in the intradermal injection recipients than in the intra- muscular recipients (32.7% vs. 9.1%). This study shows that intradermal injection of one half the dose of a commercial influenza vaccine elicits immune responses comparable to those elicited by a full dose of intramuscular vaccine among cancer patients, and it can be tolerated without serious adverse reactions.

Original languageEnglish
Pages (from-to)722-727
Number of pages6
JournalJournal of Medical Virology
Volume81
Issue number4
DOIs
Publication statusPublished - 2009 Apr

Keywords

  • Cancer
  • Influenza
  • Intradermal
  • Vaccine

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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    Jo, Y. M., Song, J. Y., Hwang, I. S., Lee, J., Oh, S. C., Kim, J. S., Kim, S. R., Kim, W. J., & Cheong, H. J. (2009). Dose sparing strategy with intradermal influenza vaccination in patients with solid cancer. Journal of Medical Virology, 81(4), 722-727. https://doi.org/10.1002/jmv.21186