Dosimetric comparison of four different external beam partial breast irradiation techniques

Three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, helical tomotherapy, and proton beam therapy

Sung Ho Moon, Kyung Hwan Shin, Tae Hyun Kim, Myonggeun Yoon, Soah Park, Doo Hyun Lee, Jong Won Kim, Dae Woong Kim, Sung Yong Park, Kwan Ho Cho

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Background and purpose: As an alternative to whole breast irradiation in early breast cancer, a variety of accelerated partial breast irradiation (APBI) techniques have been investigated. The purpose of our study is to compare the dosimetry of four different external beam APBI (EB-APBI) plans: three-dimensional conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT), helical tomotherapy (TOMO), and proton beam therapy (PBT). Methods and materials: Thirty patients were included in the study, and plans for four techniques were developed for each patient. A total dose of 30 Gy in 6 Gy fractions once daily was prescribed in all treatment plans. Results: In the analysis of the non-PTV breast volume that was delivered 50% of the prescribed dose (PD), PBT (mean: 16.5%) was superior to TOMO (mean: 22.8%), IMRT (mean: 33.3%), and 3D-CRT (mean: 40.9%) (p < 0.001). The average ipsilateral lung volume percentage receiving 20% of the PD was significantly lower in PBT (0.4%) and IMRT (2.3%) compared with 3D-CRT (6.0%) and TOMO (14.2%) (p < 0.001). The average heart volume percentage receiving 20% and 10% of the PD in left-sided breast cancer (N = 19) was significantly larger with TOMO (8.0%, 19.4%) compared to 3D-CRT (1.5%, 3.1%), IMRT (1.2%, 4.0%), and PBT (0%, 0%) (p < 0.001). Conclusions: All four EB-APBI techniques showed acceptable coverage of the PTV. However, effective non-PTV breast sparing was achieved at the cost of considerable dose exposure to the lung and heart in TOMO.

Original languageEnglish
Pages (from-to)66-73
Number of pages8
JournalRadiotherapy and Oncology
Volume90
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1
Externally publishedYes

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Proton Therapy
Conformal Radiotherapy
Intensity-Modulated Radiotherapy
Breast
Radiotherapy
Lung
Cardiac Volume
Breast Neoplasms

Keywords

  • 3D-conformal
  • Accelerated partial breast irradiation
  • Breast cancer
  • Comparison
  • Helical tomotherapy
  • Intensity-modulated radiotherapy
  • Protons

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology

Cite this

Dosimetric comparison of four different external beam partial breast irradiation techniques : Three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, helical tomotherapy, and proton beam therapy. / Moon, Sung Ho; Shin, Kyung Hwan; Kim, Tae Hyun; Yoon, Myonggeun; Park, Soah; Lee, Doo Hyun; Kim, Jong Won; Kim, Dae Woong; Park, Sung Yong; Cho, Kwan Ho.

In: Radiotherapy and Oncology, Vol. 90, No. 1, 01.01.2009, p. 66-73.

Research output: Contribution to journalArticle

Moon, Sung Ho ; Shin, Kyung Hwan ; Kim, Tae Hyun ; Yoon, Myonggeun ; Park, Soah ; Lee, Doo Hyun ; Kim, Jong Won ; Kim, Dae Woong ; Park, Sung Yong ; Cho, Kwan Ho. / Dosimetric comparison of four different external beam partial breast irradiation techniques : Three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, helical tomotherapy, and proton beam therapy. In: Radiotherapy and Oncology. 2009 ; Vol. 90, No. 1. pp. 66-73.
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abstract = "Background and purpose: As an alternative to whole breast irradiation in early breast cancer, a variety of accelerated partial breast irradiation (APBI) techniques have been investigated. The purpose of our study is to compare the dosimetry of four different external beam APBI (EB-APBI) plans: three-dimensional conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT), helical tomotherapy (TOMO), and proton beam therapy (PBT). Methods and materials: Thirty patients were included in the study, and plans for four techniques were developed for each patient. A total dose of 30 Gy in 6 Gy fractions once daily was prescribed in all treatment plans. Results: In the analysis of the non-PTV breast volume that was delivered 50{\%} of the prescribed dose (PD), PBT (mean: 16.5{\%}) was superior to TOMO (mean: 22.8{\%}), IMRT (mean: 33.3{\%}), and 3D-CRT (mean: 40.9{\%}) (p < 0.001). The average ipsilateral lung volume percentage receiving 20{\%} of the PD was significantly lower in PBT (0.4{\%}) and IMRT (2.3{\%}) compared with 3D-CRT (6.0{\%}) and TOMO (14.2{\%}) (p < 0.001). The average heart volume percentage receiving 20{\%} and 10{\%} of the PD in left-sided breast cancer (N = 19) was significantly larger with TOMO (8.0{\%}, 19.4{\%}) compared to 3D-CRT (1.5{\%}, 3.1{\%}), IMRT (1.2{\%}, 4.0{\%}), and PBT (0{\%}, 0{\%}) (p < 0.001). Conclusions: All four EB-APBI techniques showed acceptable coverage of the PTV. However, effective non-PTV breast sparing was achieved at the cost of considerable dose exposure to the lung and heart in TOMO.",
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AU - Kim, Tae Hyun

AU - Yoon, Myonggeun

AU - Park, Soah

AU - Lee, Doo Hyun

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AU - Kim, Dae Woong

AU - Park, Sung Yong

AU - Cho, Kwan Ho

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