Dosimetric evaluation of magnetic resonance imaging-based intracavitary brachytherapy for cervical cancer

Y. J. Kim, J. Y. Kim, T. H. Kim, Y. K. Lim, M. G. Yoon, J. N. Joo, S. Y. Park

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The purpose of this study was to evaluate the dosimetric benefit of magnetic resonance imaging (MRI)-based dose adaptation in intracavitary brachytherapy (ICR) for cervical cancer. Dose-volume histograms were compared between matched conventional and optimized plans in 22 patients who were treated by MRI-based ICR. Doses to organs-at-risk (OAR) and dose covering 90% of high-risk clinical target volume (HR-CTV) were evaluated to compare OAR sparing and target coverage, respectively. The probability of RTOG rectal toxicity grade of >2 in the 22 patients was estimated based on the prediction model generated from previous three-dimensional CT-based ICR data. After optimization, doses to OAR showed a statistically significant decrease. The reduction percentage (reduced dose by optimization 3 100/dose in the conventional plan) was higher in patients with HR-CTV < 20 cc than in patients with HR-CTV > 20 cc in the rectum. In patients with HR-CTV < 20 cc, the mean probability of RTOG rectal toxicity grade >2 was 67.6% for the conventional plan and 47.8% for the optimized plan, based on the prediction model. In conclusion, dose adaptation by MRI-based ICR for cervical cancer resulted in significant dose reduction to the rectum, especially in patients with HR-CTV < 20 cc.

Original languageEnglish
Pages (from-to)243-251
Number of pages9
JournalTechnology in Cancer Research and Treatment
Volume13
Issue number3
DOIs
Publication statusPublished - 2014 Jun

Keywords

  • Cervical cancer
  • DVH
  • MRI-based ICR
  • Optimization
  • Rectal toxicity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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