Dosimetric evaluation of magnetic resonance imaging-based intracavitary brachytherapy for cervical cancer

Y. J. Kim, J. Y. Kim, T. H. Kim, Y. K. Lim, Myonggeun Yoon, J. N. Joo, S. Y. Park

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The purpose of this study was to evaluate the dosimetric benefit of magnetic resonance imaging (MRI)-based dose adaptation in intracavitary brachytherapy (ICR) for cervical cancer. Dose-volume histograms were compared between matched conventional and optimized plans in 22 patients who were treated by MRI-based ICR. Doses to organs-at-risk (OAR) and dose covering 90% of high-risk clinical target volume (HR-CTV) were evaluated to compare OAR sparing and target coverage, respectively. The probability of RTOG rectal toxicity grade of >2 in the 22 patients was estimated based on the prediction model generated from previous three-dimensional CT-based ICR data. After optimization, doses to OAR showed a statistically significant decrease. The reduction percentage (reduced dose by optimization 3 100/dose in the conventional plan) was higher in patients with HR-CTV < 20 cc than in patients with HR-CTV > 20 cc in the rectum. In patients with HR-CTV < 20 cc, the mean probability of RTOG rectal toxicity grade >2 was 67.6% for the conventional plan and 47.8% for the optimized plan, based on the prediction model. In conclusion, dose adaptation by MRI-based ICR for cervical cancer resulted in significant dose reduction to the rectum, especially in patients with HR-CTV < 20 cc.

Original languageEnglish
Pages (from-to)243-251
Number of pages9
JournalTechnology in Cancer Research and Treatment
Volume13
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

Fingerprint

Brachytherapy
Uterine Cervical Neoplasms
Organs at Risk
Magnetic Resonance Imaging
Rectum

Keywords

  • Cervical cancer
  • DVH
  • MRI-based ICR
  • Optimization
  • Rectal toxicity

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Dosimetric evaluation of magnetic resonance imaging-based intracavitary brachytherapy for cervical cancer. / Kim, Y. J.; Kim, J. Y.; Kim, T. H.; Lim, Y. K.; Yoon, Myonggeun; Joo, J. N.; Park, S. Y.

In: Technology in Cancer Research and Treatment, Vol. 13, No. 3, 01.01.2014, p. 243-251.

Research output: Contribution to journalArticle

Kim, Y. J. ; Kim, J. Y. ; Kim, T. H. ; Lim, Y. K. ; Yoon, Myonggeun ; Joo, J. N. ; Park, S. Y. / Dosimetric evaluation of magnetic resonance imaging-based intracavitary brachytherapy for cervical cancer. In: Technology in Cancer Research and Treatment. 2014 ; Vol. 13, No. 3. pp. 243-251.
@article{37fba3f8505e47d49bbb961ed3bdd7da,
title = "Dosimetric evaluation of magnetic resonance imaging-based intracavitary brachytherapy for cervical cancer",
abstract = "The purpose of this study was to evaluate the dosimetric benefit of magnetic resonance imaging (MRI)-based dose adaptation in intracavitary brachytherapy (ICR) for cervical cancer. Dose-volume histograms were compared between matched conventional and optimized plans in 22 patients who were treated by MRI-based ICR. Doses to organs-at-risk (OAR) and dose covering 90{\%} of high-risk clinical target volume (HR-CTV) were evaluated to compare OAR sparing and target coverage, respectively. The probability of RTOG rectal toxicity grade of >2 in the 22 patients was estimated based on the prediction model generated from previous three-dimensional CT-based ICR data. After optimization, doses to OAR showed a statistically significant decrease. The reduction percentage (reduced dose by optimization 3 100/dose in the conventional plan) was higher in patients with HR-CTV < 20 cc than in patients with HR-CTV > 20 cc in the rectum. In patients with HR-CTV < 20 cc, the mean probability of RTOG rectal toxicity grade >2 was 67.6{\%} for the conventional plan and 47.8{\%} for the optimized plan, based on the prediction model. In conclusion, dose adaptation by MRI-based ICR for cervical cancer resulted in significant dose reduction to the rectum, especially in patients with HR-CTV < 20 cc.",
keywords = "Cervical cancer, DVH, MRI-based ICR, Optimization, Rectal toxicity",
author = "Kim, {Y. J.} and Kim, {J. Y.} and Kim, {T. H.} and Lim, {Y. K.} and Myonggeun Yoon and Joo, {J. N.} and Park, {S. Y.}",
year = "2014",
month = "1",
day = "1",
doi = "10.7785/tcrt.2012.500372",
language = "English",
volume = "13",
pages = "243--251",
journal = "Technology in Cancer Research and Treatment",
issn = "1533-0346",
publisher = "Adenine Press",
number = "3",

}

TY - JOUR

T1 - Dosimetric evaluation of magnetic resonance imaging-based intracavitary brachytherapy for cervical cancer

AU - Kim, Y. J.

AU - Kim, J. Y.

AU - Kim, T. H.

AU - Lim, Y. K.

AU - Yoon, Myonggeun

AU - Joo, J. N.

AU - Park, S. Y.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The purpose of this study was to evaluate the dosimetric benefit of magnetic resonance imaging (MRI)-based dose adaptation in intracavitary brachytherapy (ICR) for cervical cancer. Dose-volume histograms were compared between matched conventional and optimized plans in 22 patients who were treated by MRI-based ICR. Doses to organs-at-risk (OAR) and dose covering 90% of high-risk clinical target volume (HR-CTV) were evaluated to compare OAR sparing and target coverage, respectively. The probability of RTOG rectal toxicity grade of >2 in the 22 patients was estimated based on the prediction model generated from previous three-dimensional CT-based ICR data. After optimization, doses to OAR showed a statistically significant decrease. The reduction percentage (reduced dose by optimization 3 100/dose in the conventional plan) was higher in patients with HR-CTV < 20 cc than in patients with HR-CTV > 20 cc in the rectum. In patients with HR-CTV < 20 cc, the mean probability of RTOG rectal toxicity grade >2 was 67.6% for the conventional plan and 47.8% for the optimized plan, based on the prediction model. In conclusion, dose adaptation by MRI-based ICR for cervical cancer resulted in significant dose reduction to the rectum, especially in patients with HR-CTV < 20 cc.

AB - The purpose of this study was to evaluate the dosimetric benefit of magnetic resonance imaging (MRI)-based dose adaptation in intracavitary brachytherapy (ICR) for cervical cancer. Dose-volume histograms were compared between matched conventional and optimized plans in 22 patients who were treated by MRI-based ICR. Doses to organs-at-risk (OAR) and dose covering 90% of high-risk clinical target volume (HR-CTV) were evaluated to compare OAR sparing and target coverage, respectively. The probability of RTOG rectal toxicity grade of >2 in the 22 patients was estimated based on the prediction model generated from previous three-dimensional CT-based ICR data. After optimization, doses to OAR showed a statistically significant decrease. The reduction percentage (reduced dose by optimization 3 100/dose in the conventional plan) was higher in patients with HR-CTV < 20 cc than in patients with HR-CTV > 20 cc in the rectum. In patients with HR-CTV < 20 cc, the mean probability of RTOG rectal toxicity grade >2 was 67.6% for the conventional plan and 47.8% for the optimized plan, based on the prediction model. In conclusion, dose adaptation by MRI-based ICR for cervical cancer resulted in significant dose reduction to the rectum, especially in patients with HR-CTV < 20 cc.

KW - Cervical cancer

KW - DVH

KW - MRI-based ICR

KW - Optimization

KW - Rectal toxicity

UR - http://www.scopus.com/inward/record.url?scp=84898735343&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898735343&partnerID=8YFLogxK

U2 - 10.7785/tcrt.2012.500372

DO - 10.7785/tcrt.2012.500372

M3 - Article

VL - 13

SP - 243

EP - 251

JO - Technology in Cancer Research and Treatment

JF - Technology in Cancer Research and Treatment

SN - 1533-0346

IS - 3

ER -