Superparamagnetic Fe 3 O 4 nanoparticles (NPs) based nanomaterials have been exploited in various biotechnology fields including biomolecule separation. However, slow accumulation of Fe 3 O 4 NPs by magnets may limit broad applications of Fe 3 O 4 NP-based nanomaterials. In this study, we report fabrication of Fe 3 O 4 NPs double-layered silica nanoparticles (DL MNPs) with a silica core and highly packed Fe 3 O 4 NPs layers. The DL MNPs had a superparamagnetic property and efficient accumulation kinetics under an external magnetic field. Moreover, the magnetic field-exposed DL MNPs show quantitative accumulation, whereas Fe 3 O 4 NPs single-layered silica nanoparticles (SL MNPs) and silica-coated Fe 3 O 4 NPs produced a saturated plateau under full recovery of the NPs. DL MNPs are promising nanomaterials with great potential to separate and analyze biomolecules.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)