Double-layer magnetic nanoparticle-embedded silica particles for efficient bio-separation

San Kyeong, Cheolhwan Jeong, Homan Kang, Hong Jun Cho, Sung Jun Park, Jin Kyoung Yang, Sehoon Kim, Hyung Mo Kim, Bong Hyun Jun, Yoon Sik Lee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Superparamagnetic Fe 3 O 4 nanoparticles (NPs) based nanomaterials have been exploited in various biotechnology fields including biomolecule separation. However, slow accumulation of Fe 3 O 4 NPs by magnets may limit broad applications of Fe 3 O 4 NP-based nanomaterials. In this study, we report fabrication of Fe 3 O 4 NPs double-layered silica nanoparticles (DL MNPs) with a silica core and highly packed Fe 3 O 4 NPs layers. The DL MNPs had a superparamagnetic property and efficient accumulation kinetics under an external magnetic field. Moreover, the magnetic field-exposed DL MNPs show quantitative accumulation, whereas Fe 3 O 4 NPs single-layered silica nanoparticles (SL MNPs) and silica-coated Fe 3 O 4 NPs produced a saturated plateau under full recovery of the NPs. DL MNPs are promising nanomaterials with great potential to separate and analyze biomolecules.

Original languageEnglish
Article numbere0143727
JournalPloS one
Volume10
Issue number11
DOIs
Publication statusPublished - 2015 Nov 1
Externally publishedYes

Fingerprint

nanoparticles
Silicon Dioxide
silica
Nanoparticles
nanomaterials
Nanostructures
Nanostructured materials
ferrous sulfate
Biomolecules
Magnetic Fields
magnetic fields
Magnetic fields
Magnets
Biotechnology
biotechnology
plateaus
kinetics
Fabrication
Recovery
Kinetics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kyeong, S., Jeong, C., Kang, H., Cho, H. J., Park, S. J., Yang, J. K., ... Lee, Y. S. (2015). Double-layer magnetic nanoparticle-embedded silica particles for efficient bio-separation. PloS one, 10(11), [e0143727]. https://doi.org/10.1371/journal.pone.0143727

Double-layer magnetic nanoparticle-embedded silica particles for efficient bio-separation. / Kyeong, San; Jeong, Cheolhwan; Kang, Homan; Cho, Hong Jun; Park, Sung Jun; Yang, Jin Kyoung; Kim, Sehoon; Kim, Hyung Mo; Jun, Bong Hyun; Lee, Yoon Sik.

In: PloS one, Vol. 10, No. 11, e0143727, 01.11.2015.

Research output: Contribution to journalArticle

Kyeong, S, Jeong, C, Kang, H, Cho, HJ, Park, SJ, Yang, JK, Kim, S, Kim, HM, Jun, BH & Lee, YS 2015, 'Double-layer magnetic nanoparticle-embedded silica particles for efficient bio-separation', PloS one, vol. 10, no. 11, e0143727. https://doi.org/10.1371/journal.pone.0143727
Kyeong, San ; Jeong, Cheolhwan ; Kang, Homan ; Cho, Hong Jun ; Park, Sung Jun ; Yang, Jin Kyoung ; Kim, Sehoon ; Kim, Hyung Mo ; Jun, Bong Hyun ; Lee, Yoon Sik. / Double-layer magnetic nanoparticle-embedded silica particles for efficient bio-separation. In: PloS one. 2015 ; Vol. 10, No. 11.
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