Downregulation of erythroid differentiation regulator 1 as a novel marker of skin tumors

Young Bok Lee, Hee Jung Kim, Hwa Young Jung, Yong Gyu Park, Si Yong Kim, Baik Kee Cho, Daeho Cho, Hyun Jeong Park

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Summary: Background: Erythroid differentiation regulator 1 is decreased in malignant melanoma. However, the expression of erythroid differentiation regulator 1 has not been reported in normal epidermis, vessel, nerve, dermal adnexae, and various skin tumors. Methods: To investigate the expression of erythroid differentiation regulator 1 in normal skin and various skin tumors, immunohistochemical analysis of normal skin, epidermal tumors, sebaceous tumors, and eccrine tumors was performed. The image analysis was quantitatively performed using HistoQuant software. Results: Erythroid differentiation regulator 1 was strongly expressed in the nuclei of normal epidermis, sebaceous gland, eccrine gland, vessel, and nerve. Expression of erythroid differentiation regulator 1 was weak in seborrheic keratosis, sebaceous hyperplasia, and eccrine spiradenoma. Erythroid differentiation regulator 1 was rarely observed in malignant skin tumors, including squamous cell carcinoma, basal cell carcinoma, malignant melanoma, sebaceous carcinoma, and eccrine porocarcinoma. Conclusions: The expression of erythroid differentiation regulator 1 was negatively correlated with the malignant potential in various skin tumors. The results support the role of erythroid differentiation regulator 1 in cutaneous carcinogenesis and indicate its potential as a novel marker of skin tumors.

Original languageEnglish
Pages (from-to)723-730
Number of pages8
JournalInternational Journal of Dermatology
Volume53
Issue number6
DOIs
Publication statusPublished - 2014 Jun
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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    Lee, Y. B., Kim, H. J., Jung, H. Y., Park, Y. G., Kim, S. Y., Cho, B. K., Cho, D., & Park, H. J. (2014). Downregulation of erythroid differentiation regulator 1 as a novel marker of skin tumors. International Journal of Dermatology, 53(6), 723-730. https://doi.org/10.1111/ijd.12057