Downregulation of erythroid differentiation regulator 1 as a novel marker of skin tumors

Young Bok Lee, Hee Jung Kim, Hwa Young Jung, Yong Gyu Park, Si Yong Kim, Baik Kee Cho, Dae Ho Cho, Hyun Jeong Park

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Summary: Background: Erythroid differentiation regulator 1 is decreased in malignant melanoma. However, the expression of erythroid differentiation regulator 1 has not been reported in normal epidermis, vessel, nerve, dermal adnexae, and various skin tumors. Methods: To investigate the expression of erythroid differentiation regulator 1 in normal skin and various skin tumors, immunohistochemical analysis of normal skin, epidermal tumors, sebaceous tumors, and eccrine tumors was performed. The image analysis was quantitatively performed using HistoQuant software. Results: Erythroid differentiation regulator 1 was strongly expressed in the nuclei of normal epidermis, sebaceous gland, eccrine gland, vessel, and nerve. Expression of erythroid differentiation regulator 1 was weak in seborrheic keratosis, sebaceous hyperplasia, and eccrine spiradenoma. Erythroid differentiation regulator 1 was rarely observed in malignant skin tumors, including squamous cell carcinoma, basal cell carcinoma, malignant melanoma, sebaceous carcinoma, and eccrine porocarcinoma. Conclusions: The expression of erythroid differentiation regulator 1 was negatively correlated with the malignant potential in various skin tumors. The results support the role of erythroid differentiation regulator 1 in cutaneous carcinogenesis and indicate its potential as a novel marker of skin tumors.

Original languageEnglish
Pages (from-to)723-730
Number of pages8
JournalInternational Journal of Dermatology
Volume53
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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    Lee, Y. B., Kim, H. J., Jung, H. Y., Park, Y. G., Kim, S. Y., Cho, B. K., Cho, D. H., & Park, H. J. (2014). Downregulation of erythroid differentiation regulator 1 as a novel marker of skin tumors. International Journal of Dermatology, 53(6), 723-730. https://doi.org/10.1111/ijd.12057