Doxorubicin/gold-loaded core/shell nanoparticles for combination therapy to treat cancer through the enhanced tumor targeting

Kyungim Kim, Keun Sang Oh, Dal Yong Park, Jae Young Lee, Beom Suk Lee, In-San Kim, Kwang Meyung Kim, Ick Chan Kwon, Yoon Kim Sang, Soon Hong Yuk

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A combination therapy consisting of radiotherapy and chemotherapy is performed using the core/shell nanoparticles (NPs) containing gold NPs and doxorubicin (DOX). Gold NPs in the core/shell NPs were utilized as a radiosensitizer. To examine the morphology and size distribution of the core/shell NPs, transmittance electron microscopy and dynamic light scattering were used. The in vitro release behavior, cellular uptake and toxicity were also observed to verify the functionality of the core/shell NPs as a nanocarrier. To demonstrate the advantage of the core/shell NPs over traditional gold NPs reported in the combination therapy, we evaluated the accumulation behavior of the core/shell NPs at the tumor site using the biodistribution. Antitumor efficacy was observed with and without radiation to evaluate the role of gold NPs as a radiosensitizer.

Original languageEnglish
Pages (from-to)141-149
Number of pages9
JournalJournal of Controlled Release
Volume228
DOIs
Publication statusPublished - 2016 Apr 28
Externally publishedYes

Keywords

  • Combination therapy
  • Core/shell nanoparticles
  • Doxorubicin
  • Gold nanoparticles
  • Radiotherapy

ASJC Scopus subject areas

  • Pharmaceutical Science

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